A STUDY ON THE SOLUBILITY AND STABILITY OF DIAZEPAM AND NITRAZEPAM IN BUFFERED MIXTURES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 5, Volume 6, Issue 1, June 1983, Pages 69-80 PDF (341.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1983.100714 | ||
| Authors | ||
| A. E. Aboutaleb; M. S. Mesiha; A. Abdel-Zaher | ||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Diazepam and Nitrazepam were solubilized by a series of commercial nonionic surfactant solutions buffered to pH 4, 6 and 7 at 35°C. These nonionic surfactants include Eumulgin C 1000 and C 1500 and Brij 35 and 58. It was found that the surfactant and the drug molecular structure as well as the pH value affect the quantity of Diazepam and Nitrazepam solubilized. The stability of Diazepam and Nitrazepam were studied in the formulated mixtures at controlled pH values. It was found that the formulated mixtures showed maximum stability for Diazepam and Nitrazepam in mixtures adjusted to pH 6. | ||
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