Nouh, A., Mesiha, M. (1983). THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM. test, 6(1), 81-88. doi: 10.21608/bfsa.1983.100715
A. T. Nouh; M. S. Mesiha. "THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM". test, 6, 1, 1983, 81-88. doi: 10.21608/bfsa.1983.100715
Nouh, A., Mesiha, M. (1983). 'THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM', test, 6(1), pp. 81-88. doi: 10.21608/bfsa.1983.100715
Nouh, A., Mesiha, M. THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM. test, 1983; 6(1): 81-88. doi: 10.21608/bfsa.1983.100715

THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 6, Issue 1, June 1983, Pages 81-88    PDF (265.96 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1983.100715
Authors
A. T. Nouh1; M. S. Mesiha2
1Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Stearic acid was used for the preparation of solid dispersion systems containing sodium Phanobarbitone in ratios of 1:2,1:1, 2:1 drug: carrier respectively. The dispersion prepared by melting and sudden cooling was passed through a set of standard sieves and tested for in vitro release rate. The release was slow for large particle size fractions and for systems containing high stearic acid content.
A diffusional model was assessed for the drug release from the solid dispersion by a linear correlation observed between the percent release of the drug and the square root of time.
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