El-Shabouri, S., Amer, M., Taha, A., Khashaba, P. (1983). SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE. test, 6(1), 226-242. doi: 10.21608/bfsa.1983.100956
S. R. El-Shabouri; M. M. Amer; A. M. Taha; P. Y. Khashaba. "SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE". test, 6, 1, 1983, 226-242. doi: 10.21608/bfsa.1983.100956
El-Shabouri, S., Amer, M., Taha, A., Khashaba, P. (1983). 'SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE', test, 6(1), pp. 226-242. doi: 10.21608/bfsa.1983.100956
El-Shabouri, S., Amer, M., Taha, A., Khashaba, P. SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE. test, 1983; 6(1): 226-242. doi: 10.21608/bfsa.1983.100956

SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE

Bulletin of Pharmaceutical Sciences Assiut University
Article 15, Volume 6, Issue 1, June 1983, Pages 226-242    PDF (465.5 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1983.100956
Authors
S. R. El-Shabouri; M. M. Amer; A. M. Taha; P. Y. Khashaba
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
A spectrophotometric assay procedure was developed for the quantitative assay of piperazine and phenmetrazine. The method is based on the formation of enamines of these drugs by interaction with acetaldehyde. The resulting enamines interact with chloranil to form the corresponding blue aminovinylquinone which can be quantitated spectrophotometrically at lmax 320 nm for both drugs and at lmax '667 nm and 67C nm for piperazine and phenmetrazine respectively. The Beer-Lambert law adhered to over the 0.5-20 ug/ml range for both drugs at both lmax. The optimum reaction conditions and the effect of variables have been studied. The method has been applied successfully to the analysis of commercially available piperazine tablets, ampoules and effervescent granules.
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