CNS DEPRESSANT, ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CERTAIN OXANILAMIDE DERIVATIVES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 15, Volume 6, Issue 2, December 1983, Pages 450-461 PDF (368.61 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1983.102101 | ||
| Author | ||
| H. I. El-Bitar | ||
| Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The present study was designed to evaluate the CNS depressant, analgesic and antiinflammatory activity of six N- {D-threo(-)-1-(p-nitrophenyl)-1,3-dihydroxyisopropyl}-N-4-substituted carbamyol-3-hydroxyoxanilamides. The CNS depressant activity of these compounds was evaluated by measuring their effects on the spontaneous motor activity of mice using the actophotometer technique, while the analgesic activity was evaluated by means of the writhing method. The antiinflammatory response was measured in rats by the trypan blue method. Aspirin was used in these experiments as a reference drug for comparative purposes. This study revealed that the compounds in question possess certain degree of CNS depressant and analgesic activity comparable but less than that of aspirin. Variable degrees of antiinflammatory activity were observed and the effectiveness of some of these compounds was almost comparable to that of aspirin. The possible correlation between the chemical structure and pharmacological activity was proposed. | ||
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