Cytotoxicity of New Selenoimine, Selenonitrone and Nitrone Derivatives Against Human Breast Cancer MDA-MB231 Cells | ||
| Egyptian Journal of Chemistry | ||
| Article 38, Volume 63, Issue 11, November 2020, Pages 4607-4613 PDF (1.17 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2020.31747.2675 | ||
| Authors | ||
| Batool Saleh Haddad1; Ali A. A. Al-Shawi* 2 | ||
| 11Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq | ||
| 22 Basrah - Iraq University of Basrah College of Education for Pure Sciences Chemistry department | ||
| Abstract | ||
| A series of new nitrone, selenoimine and selenonitrone derivatives were synthesized. Nitrone and selenonitrone derivatives were synthesized through the condensation reaction between N-mono substitutedhydroxylamine and carbonyl compounds substituted with electron donating groups, such as di(4-methoxy)benzoyl diselenide, 4-(N, N-dimethylamino) benzoyl selenonitrile and 4, 4'-di(N, N- dimethylamino)benzil, afforded a variety of new nitrone and selenonitrone compounds. Selenoimine derivative was synthesized through the condensation reaction between tert-butyl amine and (4-methoxybenzoyl selenonitrile). The yield of synthesized compounds (N1, N2, N3, N4 and N5 were (66, 60, 61, 62 and 45) %, respectively. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, elemental analysis and Mass spectroscopy. Cytotoxicity of selenonitrone (N1) and selenoimine (N3) derivatives against breast cancer cells (MDA-MB231) were evaluated for 24 and 48 h via MTT assay. The IC50 value of compound N1 were 1.714 and 1.897 µM for 24 h and 48 h, respectively. The IC50 values of compound N3 were 1.438 and 2.469 µM for 24 h and 48 h, respectively. The results suggested selenonitrone (N1) and selenoimine (N3) as anti-breast cancer potential lead compound with future merit investigations. | ||
| Keywords | ||
| Benzil; MTT assay; Nitrone; Selenocarbonyl; Selenoimine; Selenonitrones | ||
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