EFFECT OF DIRECTLY COMPRESSIBLE VEHICLES ON UNIFORMITY OF CONTENTS OF OXYTETRACYCLINE HYDROCHLORIDE TABLETS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 15, Volume 5, Issue 1, 1982, Pages 199-209 PDF (325.05 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1982.103059 | ||
| Authors | ||
| A. E. Aboutaleb; M. A. Attia; F. S. Habib | ||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The effect of microcrystalline cellulose (Avicel), Anhydrous lactose U.S.P., STA-R 1500 and Celutab, on the uniformity of contents of directly compressed oxytetracycline hydrochloride tablets was studied. The vehicles were used singly or in binary mixtures in the ratios 1:1, 3:1 and 1:3. Three different concentrations of vehicles were used plus the control 19.6, 32.6, 42% w/w. It was found that single vehicles produced uniform tablets except those containing high concentration of celutab. On the other hand the uniformity of drug contents of the tablets containing various concentrations of blends of vehicles was found to vary according to the physical properties and the concentrations of the excipients used. | ||
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