Metwally, M., Sadiq, A., Samn, A., Hemida, M. (2020). Immunological Profile of Type II Egyptian Diabetic Patients. test, 12(2), 1-14. doi: 10.21608/eajbsz.2020.103183
Metwally Gamal Metwally; Adham Gamal Sadiq; Alaa Abd-Elaziz Samn; Mahmoud Haddad Hemida. "Immunological Profile of Type II Egyptian Diabetic Patients". test, 12, 2, 2020, 1-14. doi: 10.21608/eajbsz.2020.103183
Metwally, M., Sadiq, A., Samn, A., Hemida, M. (2020). 'Immunological Profile of Type II Egyptian Diabetic Patients', test, 12(2), pp. 1-14. doi: 10.21608/eajbsz.2020.103183
Metwally, M., Sadiq, A., Samn, A., Hemida, M. Immunological Profile of Type II Egyptian Diabetic Patients. test, 2020; 12(2): 1-14. doi: 10.21608/eajbsz.2020.103183

Immunological Profile of Type II Egyptian Diabetic Patients

Egyptian Academic Journal of Biological Sciences, B. Zoology
Article 1, Volume 12, Issue 2, December 2020, Pages 1-14    PDF (720.35 K)
Document Type: Original Article
DOI: 10.21608/eajbsz.2020.103183
Authors
Metwally Gamal Metwally1; Adham Gamal Sadiq1; Alaa Abd-Elaziz Samn1; Mahmoud Haddad Hemida2
1Department of Zoology, Faculty of Science, Al-Azhar University, Madinat Nasr, Cairo, Egypt
2Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Madinat Nasr, Cairo, Egypt
Abstract
Background: Diabetes mellitus (DM) and its associated secondary complications are some of the leading induce of deaths worldwide. Aim: The aim of the study is to estimate changes in the levels of biochemical parameters as fasting blood sugar (FBS), postprandial blood sugar (PP2BS) and glycosylated hemoglobin (HbA1c); and immunological parameters as Complement proteins C3, Complement proteins C4, Immunoglobulin's (IgA, IgE, IgG, and IgM) and C-peptide of type 2 diabetic patients to obtain a full immunological and physiological profile for type 2 diabetes. Subjects and Methods: Blood samples from 25 type 2 diabetic patients and 5 healthy subjects were randomly selected from Banha University hospitals in Kalyubiyya, Egypt. Serum sugar and glycosylated hemoglobin were assayed by using chemical analyzer (chem 7). C3, C4, IgA, IgE, IgG, IgM and C-peptide were measured by ELISA Results: FBS, PP2BS, and HbA1c significant increase in type 2 diabetic patients compared to healthy subjects. C3, IgA, IgE, IgG, and C-peptide showed a significant increase in type 2 diabetic patients compared to healthy subjects. Conclusion: FBS, PP2BS, and HbA1c used as good tools for the diagnosis of diabetes mellitus. Type 2 diabetes in the current studied subjects is characterized by alternative pathway activation. Immunological biomarkers such as C3, IgA, IgE, and IgG were increased in type 2 diabetic patients by poor control of diabetes and long duration of disease. 
Keywords
Diabetes mellitus; immunological parameters; Egypt
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