Depression symptoms and Risk of Incident Asthma in Adults | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 28, Volume 70, Issue 10, January 2018, Pages 1867-1872 PDF (255.94 K) | ||
| Document Type: Original Article | ||
| Authors | ||
| Hanan Showei H Fageeh1; Mohammed Meshal A Almeshal2; Saleh Fouad M Merza3; Musaad Saad S Albalood2; Nayef Muaazzi Saleh Alblowi4; Bahna Mohammed Bahna Alsahabi5; Abeer Abdalaziz Al Hatim6; Murad Ahmed Bahidan7; Lujain Jamal M Alfattany8; Shaher Shakir S Abdulrahim9; Ahmed Ali R. Alghamdi10; Hassan Hamadan N Aljohani11 | ||
| 1ER, East Jeddah Hospital | ||
| 2Imam Muhammad ibn Saud Islamic University | ||
| 3Service , East Jeddah Hospital | ||
| 4General Physician, King Salman Armed Forces Hospital - North Western Region, | ||
| 5King Khalid University | ||
| 6Al Maarefa College | ||
| 7Yanbu General Hospital | ||
| 8King Abdulaziz University | ||
| 9Jeddah University | ||
| 10Alamal Hospital, Jeddah | ||
| 11Primary health care -Almuntazh Alsharqi, Hail | ||
| Abstract | ||
| Background: Earlier studies have recommended that asthmatic patients regularly have comorbid depression; nonetheless, temporal associations remain uncertain. Objectives: To determine whether depression predicts asthma and, on the other hand, whether asthma expects depression. Methods: A literature search was conducted without language restrictions using Pubmed, Embase, Cochrane and PsycINFO for studies published before April, 2017. Papers referenced by the obtained articles were correspondingly reviewed. Only comparative prospective studies with reported risk estimates of the association between depression and asthma were included. In order to examine whether one of these conditions was predictive of the other, studies were excluded if enrolled participants had pre-existing depression or asthma. A random effects model was used to calculate the pooled risk estimates for two outcomes: depression predicting asthma and asthma predicting depression. Results: Seven citations, derived from 8 cohort studies, met our inclusion criteria. Of these, six studies reported that depression predicted incident adult-onset asthma, including 83,684 participants and 2,334 incident cases followed for 8 to 20 years. Conversely, two studies reported that asthma predicted incident depression. These studies involved 25,566 participants and 2,655 incident cases followed for 10 and 20 years, respectively. The pooled adjusted relative risks (RRs) of acquiring asthma associated with baseline depression were 1.43 (95% CI, 1.28–1.61) (P<0.001). The adjusted RRs for acquiring depression associated with baseline asthma was 1.23 (95% CI, 0.72–2.10) (P = 0.45). Conclusions: Depression was associated with a 43% increased risk of developing adult-onset asthma. However, asthma did not increase the risk of depression based on limited studies. Further prospective studies confirming the true association between asthma and subsequent risk of depression are warranted. | ||
| Keywords | ||
| depression; Asthma; Depression predicting asthma; Asthma predicting depression | ||
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