Predictive Value of Serum and Urinary Adiponectin in Systemic Lupus Erythematosus Activity and Lupus Nephritis | ||
| Egyptian Journal of Rheumatology and Clinical Immunology | ||
| Article 10, Volume 2, Issue 1, January 2014, Pages 53-62 PDF (381.25 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrci.2014.10424 | ||
| Authors | ||
| Tamer Elbedewy1; Medhat Ghazy2; Enaam Rabee3; Eiman Hasby4 | ||
| 1Department of Internal Medicine, Tanta University; Egypt | ||
| 2Department of Internal Medicine,Tanta University; Egypt | ||
| 3Department of Clinical Pathology, Tanta University; Egypt | ||
| 4Department of Pathology, Tanta University; Egypt | ||
| Abstract | ||
| Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by chronic inflammation. Lupus nephritis is a severe manifestation of SLE affecting about 50% of SLE patients with high morbidity and mortality. Adiponectin has anti-inflammatory properties. Adiponectin could be a factor linking inflammation in SLE and lupus nephritis (LN). Aim of the Work: To assess the level of serum & urinary adiponectin in SLE patients and to detect any relation between serum & urinary adiponectin levels and SLE activity and lupus nephritis. Subjects and Methods: This study included 30 female SLE patients and 15 female age matched healthy controls. SLE patients were subjected to full history taking, clinical examination and laboratory investigations of SLE & LN. Disease activity and renal involvement were assessed using SLE Disease Activity Index (SLEDAI) and Renal SLEDAI respectively. Patients were divided into active versus inactive and LN versus non-LN. Renal biopsies were taken from LN subgroup. Serum & urinary levels of adiponectin were measured using enzyme-linked immunosorbent assay (ELISA) in all subjects. Results: Significantly higher serum & urinary adiponectin level was found in SLE patients when compared with controls. Significantly higher serum & urinary adiponectin level was found among active SLE patients when compared with inactive patients as well as among patients with LN when compared to patients without LN. Significantly higher serum & urinary adiponectin level was found among inflammatory LN class (III & IV) patients when compared to noninflammatory LN class (I & II). Serum & urinary adiponectin had a significant positive correlation with SLEDAI, renal SLEDAI, ESR 1st hour, proteinuria , anti-ds (DNA) titre and LN class while inverse correlation with C3 titre and C4 titre , also inverse correlation between urinary adiponectin and creatinine clearance were observed. Conclusion: Serum & urinary adiponectin levels are elevated in SLE patients and strongly associated with lupus activity & LN, so they may consider promising biomarkers for prediction of SLE activity & renal involvement especially urinary adiponectin in lupus nephritis. | ||
| Keywords | ||
| Systemic lupus erythematosus; adiponectin; Lupus nephritis | ||
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