Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 3, Volume 80, Issue 3, July 2020, Pages 964-970 PDF (829.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2020.104304 | ||
| Authors | ||
| Eman G.E. Helal* 1; Aisha Almutairi2; Mohamed A. Abdelaziz3; Asmaa A. H. Mohamed1 | ||
| 1Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Egypt | ||
| 2Department of Pediatrics, College of Medicine, Qassim University, Saudi Arabia. | ||
| 3Department of Physiology, Faculty of Medicine (Boys), Al-Azhar University, Egypt | ||
| Abstract | ||
| Background: Food additives are a substance added to food to enhance its flavor or appearance or to preserve it. They are widely used nowadays. Objectives: The aim of the current work was to determine the hazardous effects of sodium nitrate, fast green and glycine on some physiological parameters such as liver enzymes, lipid profile , hormonal assays …etc. Materials and methods: This study has been done on forty male albino rats. The Animals were divided into four groups: Group I (Control untreated group), Group II (fast green-treated group), Group III (glycine-treated group) and Group IV (sodium nitrate-treated group). Estimation of some biochemical parameters (liver enzymes, kidney function tests, glucose, protein profile and lipid profile) and hormonal assays [testosterone, T3 (triiodothyronine), T4 (thyroxine) and insulin were done. Results: Body weight showed highly significant decreased in both sodium nitrate and fast green . There was an increase in the activities of AST and ALT as well as urea and creatinine, in both sodium nitrate and fast green groups. There was a decrease in plasma proteins in both fast green and sodium nitrate groups. Lipid profile [total cholesterol (TC), triglycerides (TG), very low-density lipoprotein-cholesterol (VLDL-chol) and low-density lipoprotein-cholesterol (LDL-chol)] were decreased in fast green-treated groups while high-density lipoprotein-cholesterol (HDL-chol) was increased. In sodium nitrate group, the lipid profile (TC, TG, VLDL and LDL) were increased while HDL was decreased. Serum glucose, insulin, and HOMA-IR (insulin resistance) were decreased in fast green-treated group and increased in sodium nitrate-treated group. There was a increase in T3 and T4 in fast green-treated group while were decreased in sodium nitrate-treated group. Testosterone decreased in fast green-, glycine- and sodium nitrate-treated groups. While glycine-treated group showed the same results as the control group. Conclusion: It could be concluded that minimizing the use of food additives protects young children and mature people from their destructive effects. | ||
| Keywords | ||
| Food additives; Thyroid hormones; Glycine; Sodium nitrite; Fast green | ||
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