Shahin, M., Allam, A., Elkholy, R., Lashin, H. (2020). Hematological parameters as early predictors of delayed neurological sequelae in acute carbon monoxide poisoning.. test, 35(2), 61-72. doi: 10.21608/ajfm.2020.104446
Marwa Shahin; Alzahraa Allam; Rasha Elkholy; Heba Lashin. "Hematological parameters as early predictors of delayed neurological sequelae in acute carbon monoxide poisoning.". test, 35, 2, 2020, 61-72. doi: 10.21608/ajfm.2020.104446
Shahin, M., Allam, A., Elkholy, R., Lashin, H. (2020). 'Hematological parameters as early predictors of delayed neurological sequelae in acute carbon monoxide poisoning.', test, 35(2), pp. 61-72. doi: 10.21608/ajfm.2020.104446
Shahin, M., Allam, A., Elkholy, R., Lashin, H. Hematological parameters as early predictors of delayed neurological sequelae in acute carbon monoxide poisoning.. test, 2020; 35(2): 61-72. doi: 10.21608/ajfm.2020.104446

Hematological parameters as early predictors of delayed neurological sequelae in acute carbon monoxide poisoning.

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Article 7, Volume 35, Issue 2, July 2020, Pages 61-72    PDF (963.26 K)
Document Type: Original Article
DOI: 10.21608/ajfm.2020.104446
Authors
Marwa Shahin1; Alzahraa Allam2; Rasha Elkholy3; Heba Lashin1
1Forensic Medicine and Clinical Toxicology Department, Faculty of medicine, Tanta University, Tanta, Egypt.
2Internal Medicine Department, Faculty of medicine, Tanta University, Tanta, Egypt.
3Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abstract
Introduction: Delayed neurological sequelae (DNS) are the most frequent morbidity after acute carbon monoxide (CO) poisoning. Therefore, their prevention and early prediction are the main goal of treatment. Aim of the work: This study aimed to investigate parameters based on peripheral complete blood cell count (CBC) as predictors of DNS in acute CO poisoning. Methodology: It included 67 acutely CO poisoned patients and 38 healthy volunteers. On admission, history, clinical examination and routine laboratory investigations were done. Ratios based on CBC counts were measured. Patients were followed up along 6 months for DNS signs. Results: The results revealed that total white blood cells (WBC) count, absolute neutrophil count & percentage and median values of neutrophil-lymphocyte ratio (NLR) & systemic immune inflammation index (SII) were significantly higher while lymphocytes percentage, absolute monocytic count and percentage were significantly lower in CO poisoned patients compared to control group. DNS-complicated patients had significantly lower total WBC count, absolute neutrophil count & percentage and significantly higher median values of NLR and SII than non-complicated. Based on receiver operating characteristic analysis (ROC), NLR and SII were significant predictors of DNS. Conclusion: It was concluded that, NLR and SII ratios may be helpful predictors of DNS after acute CO poisoning. 
Keywords
Carbon monoxide poisoning; neutrophils; systemic immune inflammation index; delayed neurological sequelae; prognosis
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