APPLICATION OF DIALYSIS UNDER PRESSURE FOR INVESTIGATING THE INTERACTION BETWEEN CHLORAMPHENICOL AND NON-IONIC SURFACTANTS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 9, Volume 4, Issue 1, 1981, Pages 120-132 PDF (352.58 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1981.104593 | ||
| Authors | ||
| A. E. Aboutaleb; A. Abdelzaher | ||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Ultrafiltration technique was applied for investigating undersaturated systems containing chloramphenicol using Diaflo membrane UM 05. This drug was solubilized by a series of non-ionic surfactants which include Tween 20, Tween 40, Tween 60, Tween 80, Emulgin C1000, Emulgin C1500, Myrj 52, Myrj 53 and Myrj 59, at two different temperatures. It was found that the amount of chloramphenicol bound to the micelles as calculated from the ultrafiltration experiments was greater for Emulgin C1000, than Emulgin C1500 on the other hand the binding capacity of the different Tweens for chloramphenicol can be arranged as follows: Tween 80 > Tween 40 > Tween 60 > Tween 20. For Myrj series, Myrj 52 was found to be greater than Myrj 53 and both were higher than Myrj 59. | ||
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