THE USE OF MOLECULAR SIEVE TECHNIQUE FOR STUDYING UNDERSATURATED SYSTEMS CONTAINING CHLORAMPHENICOL | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 10, Volume 4, Issue 1, 1981, Pages 133-150 PDF (576.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1981.104594 | ||
| Authors | ||
| A. E. Aboutaleb; A. Abdelzaher | ||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Molecular sieve technique was carried out using sephadex G 25 fine for investigating the under-saturated systems containing chloramphenicol. This drug was solubilized by a series of commerical non-ionic surfactants which include: Tween 20, Tween 40, Tween 60, Tween 80, EmulginC1000, Emulgin C1500, Myrj 52, Myrj 53 and Myrj 59. At two different temperatures 25 and 35° it was found that the amount of chloramphenicol incorporated within the micelle as calculated by the molecular sieve technique was greater for Emulgin 1000 than Emulgin 1500, on the other hand for Tween series the following sequence was obtained: Tween 80 > Tween 40 > Tween 60 > Tween 20. For Myrj series Myrj 52 was greater than Myrj 53 which in turn was higher than Myrj 59. The results obtained by investigating the under-saturated systems using this technique agreed with those determined by solubility method and gave further support to the partition model of solubilization and prove the validity of using this technique for investigating undersaturated solubilized systems containing non-ionic surfactants. | ||
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