El-Koussi, A., Abdel-Aleem, A., Afifi, A. (1978). ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES. test, 1(1), 151-161. doi: 10.21608/bfsa.1978.104913
A. A. El-Koussi; A. M. Abdel-Aleem; A. M. Afifi. "ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES". test, 1, 1, 1978, 151-161. doi: 10.21608/bfsa.1978.104913
El-Koussi, A., Abdel-Aleem, A., Afifi, A. (1978). 'ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES', test, 1(1), pp. 151-161. doi: 10.21608/bfsa.1978.104913
El-Koussi, A., Abdel-Aleem, A., Afifi, A. ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES. test, 1978; 1(1): 151-161. doi: 10.21608/bfsa.1978.104913

ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 1, Issue 1, 1978, Pages 151-161    PDF (436.18 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1978.104913
Authors
A. A. El-Koussi1; A. M. Abdel-Aleem2; A. M. Afifi1
1Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
The present study was aimed at evaluating the anti-inflammatory action and toxicity of seven N-[-l-(p-nitrophenyl)-l,3-dihydroxy isopropyl]-N'-(substituted) oxamides (1). The compounds are designed to include the following moieties: anthranilic and p-aminosalicylic acids and p-aminophenol in their basic structures. Two dose levels of these compounds were assessed for their anti--inflammatory property in rate by the trypan blue method and using acetyl salicylic acid as the reference anti-inflammatory agent. Median lethal doses of the compounds were determined in mice.
The possible correlation between structure and biological activity is suggested.
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