SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 11, Volume 1, Issue 1, 1978, Pages 163-174 PDF (513.87 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1978.104914 | ||
| Authors | ||
| M. Atef Abdelkader; Aly M. Taha | ||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| A spectrophotometric method is described for the determination of some N-ethyl drugs via reaction with chloranil. A mixture of a solution of' the amine in benzene with the chromogenic reagent was heated on a water bath at 75-80° for one hour. A blue colored product lmax 680 nm resulted. Apparent molar absorptivities of the chromogenic product of tertiary N-ethyl compounds ranged from 1700-5100. Under the described assay conditions N-methyl as well as quaternized N-ethyl compounds did not interfere. The amines are asseyed in the range of 0.004 - 1.3 mg per ml range with an accuracy of 99-101% recovery and a S.D. of ± 0.74- ± 3.11.%. The possible composition of the colored product is discussed. | ||
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