Stromal CD10 immunohistochemical expression in urothelial carcinoma of urinary bladder and correlation with clinicopathological parameters | ||
| SECI Oncology Journal | ||
| Article 1, Volume 5, Issue 4, October 2017, Pages 48-57 PDF (600.83 K) | ||
| DOI: 10.21608/secioj.2017.10540 | ||
| Abstract | ||
| CD10 is widely expressed in various tumor types and their surrounding cancer associated fibroblasts; and correlate with poor prognosis. In present study CD10 immunohistochemical expression in stromal fibroblasts surrounding urothelial carcinoma and its relationship with clinicopathological parameters were investigated. Patients and Methods: Formalin-fixed paraffin embedded tissue sections from 106 urothelial cancer specimens were stained with CD10 antibody using immunohistochemistry technique. Expression of CD10 in the stromal cells was then analysed to evaluate its association with different clinicopathological variables. Results: Stromal CD10 expression was significantly associated with each of high grade (P<0.001), invasive tumor, advanced stage (P<0.001), squamous differentiation of tumor cells (P=0.02) and papillary architecture (P<0.001). There was no significant association between stromal CD10 expression and, and patient age, sex and tumor size. Conclusion: Increased expression of CD10 in cancer associated fibroblasts was strongly correlated with tumor progression and invasion | ||
| Keywords | ||
| CD10; stroma; urothelial; stage; Grade; Papillary; Bilharziasis | ||
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