Fawzy, R., EL-Akhras, A., El Said, H., Amer, A. (2023). Brain Metabolic Alteration and Neuropsychiatric Dysfunctions in Childhood - onset Systemic Lupus Erythematosus. test, 29(1.1), 112-118. doi: 10.21608/zumj.2020.32604.1878
Reham Mohamed Fawzy; Ahmed Gamal EL-Akhras; Hany El Said; Ayman Amer. "Brain Metabolic Alteration and Neuropsychiatric Dysfunctions in Childhood - onset Systemic Lupus Erythematosus". test, 29, 1.1, 2023, 112-118. doi: 10.21608/zumj.2020.32604.1878
Fawzy, R., EL-Akhras, A., El Said, H., Amer, A. (2023). 'Brain Metabolic Alteration and Neuropsychiatric Dysfunctions in Childhood - onset Systemic Lupus Erythematosus', test, 29(1.1), pp. 112-118. doi: 10.21608/zumj.2020.32604.1878
Fawzy, R., EL-Akhras, A., El Said, H., Amer, A. Brain Metabolic Alteration and Neuropsychiatric Dysfunctions in Childhood - onset Systemic Lupus Erythematosus. test, 2023; 29(1.1): 112-118. doi: 10.21608/zumj.2020.32604.1878

Brain Metabolic Alteration and Neuropsychiatric Dysfunctions in Childhood - onset Systemic Lupus Erythematosus

Zagazig University Medical Journal
Article 17, Volume 29, Issue 1.1, January 2023, Pages 112-118    PDF (423.36 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.32604.1878
Authors
Reham Mohamed Fawzy* 1; Ahmed Gamal EL-Akhras2; Hany El Said3; Ayman Amer4
1pediatric department, Faculty of Medicine, Zagazig University,Zagazig,Egypt
2pediatrics, faculty of medicine,Zagazig university,zagazig,Egypt
3Department of Pediatrics, Faculty of Medicine , Zagazig University, Zagazig, Sharkia, Egypt.
4radiodiagnosis department, faculty of medicine, zagazig university, zagazig, egypt.
Abstract
Background:
Neuropsychiatric Lupus Erythematosus (NPSLE) is the main cause for morbidity and mortality in systemic lupus erythematosus. NPSLE is difficult for the diagnosis. MRS plays an important role for early diagnosis of NPSLE before appearance of neuropsychiatric manifestations and this by the help of neurocognitive assessment tests.
Subjects and Methods:
In this study, we select 30 patients with SLE, aged from 9-17 years old. Then divided them to two groups .one group has neuropsychiatric manifestations and the other group show non neuropsychiatric manifestations use Magnetic Resonance spectroscopy (MRS) to assess any metabolic brain alteration causing neuropsychiatric disorders and compare the results between the two groups results.
Results:
One hundred percent of patients in the study shows abnormal MRS findings instead of only, 36.7% of the studied group shows neuropsychiatric manifestations. There were non- significance differences between both studied groups in MRS findings. There was statistical significance increase in the NPSLE cases than others according to the presence of lupus anti -coagulant antibody.
Conclusion:
NPSLE can be diagnosed easily by MRS for early management which improve the quality of patient’s life. MRS can also detect disease activity very early for reevaluation of management and the efficacy of treatment.
Keywords
SLE; MRS; NPSLE
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