Preparation, Characterization of Copper Complex and its Biological Activity | ||
| Research Journal of Applied Biotechnology | ||
| Article 7, Volume 4, Issue 2, November 2018, Pages 58-67 PDF (397.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rjab.2018.106811 | ||
| Authors | ||
| Samar A. Aly* 1; Hanaa El-Boraey2; Ayman S. Eldourghamy1; Amal Mosbah1 | ||
| 1Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt. | ||
| 2Department of Chemistry, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt | ||
| Abstract | ||
| Thiosemicarbazones and their metal complexes are very promising compounds which present awide range of pharmacological applications as antimicrobial, antiparasital, and antiviral agents In many circumstances the pharmacological activity of thiosemicarbazones increases upon coordination to metal ions. A new novel copper complex of thiosemicarbazide ligand has been prepared and characterized by different physical and chemical methods such as 1H NMR Spectroscopy, IR spectra, elemental analysis, molar conductance, electronic spectra and magnetic susceptibilities measurements. Copper complex behaves as a neutral tridentate in nature , coordination takes place via carbonyl oxygen , N(2)H and C=S respectively .Also the study of the effect of gamma irradiation on ligand andCu(I) complex using different measurments devices. On the other side, the antibacterial activity of ligand and Cu(I) complex against gram positive (Streptococcus pyogenes) and gram negative( Escherichia coli) bacteria was investigated. The result revealed that Cu( I) complex after gamma irradiation showed a higher antibacterial activity against gram positive (Streptococcus pyogenes) and gram negative(Escherichia coli) bacteria than the ligand | ||
| Keywords | ||
| Copper complex; IR; Thermal analysis; Antibacterial; Gamma irradiation | ||
|
Statistics Article View: 208 PDF Download: 428 |
||
