Serum Netrin-1 and Asymmetric Dimethylarginine as Biomarkers of Acute and Chronic Carbon Monoxide Poisoning | ||
| Mansoura Journal of Forensic Medicine and Clinical Toxicology | ||
| Article 6, Volume 29, Issue 1, January 2021, Pages 1-16 PDF (1.24 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjfmct.2020.34651.1020 | ||
| Authors | ||
| Eslam Metwally1; Omayma Hassan2; Abdelmonem Madboly* 3 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Egypt | ||
| 2Community, Environmental and Occupational Medicine Department, Faculty of Medicine, Benha University, Egypt | ||
| 3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha University, Egypt | ||
| Abstract | ||
| Diagnosis of carbon monoxide (CO) poisoning is done traditionally by detecting carboxyhemoglobin (COHb) level. However, the severity of clinical manifestations is unrelated to the absolute levels of COHb. Netrin-1 (Net-1) is a protein with anti-inflammatory and anti-apoptotic properties while asymmetric dimethylarginine (ADMA) is an oxidative stress indicator. This study aimed at assessing and comparing between Net-1, ADMA and COHb as biomarkers in CO poisoning. This cross-sectional clinical study was carried out on 30 acutely CO poisoned adults admitted to Benha Poisoning Control Unit, Benha University Hospitals; 30 chronic CO exposed workers at four different car service centres, plus 30 healthy controls. Results showed a positive correlation between serum levels of Net-1 and ADMA and the severity of acute CO poisoning both on admission, and after oxygen therapy. There was a positive correlation between COHb level and both serum levels of Net-1 and ADMA in chronic cases. In conclusion: COHb level can only support the initial diagnosis of acute CO poisoning. Both ADMA and Net-1 are better biomarkers in assessing the severity of acute CO poisoning, where ADMA is better than Net-1. In diagnosis of chronic CO poisoning, both ADMA and Net-1 are as dependable as COHb. | ||
| Keywords | ||
| netrin-1; asymmetric dimethylarginine; carbon monoxide poisoning; biomarkers; clinical study | ||
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