STUDY OF THE EFFECT OF ACTIVE INFECTIONS ON DIHYDRORHODAMINE (DHR) TEST IN CHRONIC GRANULOMATOUS DISEASE PATIENTS (CGD) | ||
| ALEXMED ePosters | ||
| Article 1, Volume 2, Issue 1, August 2020, Pages 1-2 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2020.38715.1003 | ||
| Author | ||
| shady samy kamal* | ||
| Clinical pathology, Faculty of medicine, Alexandria university, Alexandria, Egypt | ||
| Abstract | ||
| Chronic granulomatous disease (CGD) is the most common type of primary innate immune deficiency caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme in the neutrophils. (1) It’s considered as a fatal granulomatous disease of childhood as most patients with CGD die by 10 years of age. (2) Any mutation at one of the genes encoding for glycoproteins that are forming the five subunits of the NADPH oxidase enzyme leads to CGD. If the mutation leaves some residual NADPH oxidase activity intact the clinical expression of the disease is attenuated and prognosis is better. (3) CGD can be treated by conventional treatment, stem cell transplantation or genetic therapy. (4) The (DHR) test was approved to be the gold standard for diagnosis of CGD. (5) Aim of the work The aim of the present study is to detect the effect of active infections on the interpretation of DHR test results in chronic granulomatous disease patients and patients with active infections with no evidence of CGD. | ||
| Keywords | ||
| CGD; DHR; infections | ||
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