(2020). CORRELATION BETWEEN CLINICAL AND ECHOCARDIOGRAPHIC FINDINGS WITH THE OCCURRENCE OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH MITRAL VALVE PROLAPSE. test, 41(1), 1-5. doi: 10.21608/jmalexu.2020.108437
. "CORRELATION BETWEEN CLINICAL AND ECHOCARDIOGRAPHIC FINDINGS WITH THE OCCURRENCE OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH MITRAL VALVE PROLAPSE". test, 41, 1, 2020, 1-5. doi: 10.21608/jmalexu.2020.108437
(2020). 'CORRELATION BETWEEN CLINICAL AND ECHOCARDIOGRAPHIC FINDINGS WITH THE OCCURRENCE OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH MITRAL VALVE PROLAPSE', test, 41(1), pp. 1-5. doi: 10.21608/jmalexu.2020.108437
CORRELATION BETWEEN CLINICAL AND ECHOCARDIOGRAPHIC FINDINGS WITH THE OCCURRENCE OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH MITRAL VALVE PROLAPSE. test, 2020; 41(1): 1-5. doi: 10.21608/jmalexu.2020.108437

CORRELATION BETWEEN CLINICAL AND ECHOCARDIOGRAPHIC FINDINGS WITH THE OCCURRENCE OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH MITRAL VALVE PROLAPSE

Journal of the Medical Research Institute
Article 1, Volume 41, Issue 1, August 2020, Pages 1-5    PDF (581.33 K)
DOI: 10.21608/jmalexu.2020.108437
Abstract
Background: Chronic Mitral valve prolapse (MVP) has been linked to the occurrence of serious ventricular arrhythmias and sudden cardiac death. However, their mechanism is not fully understood particularly in the absence of haemodynamically significant mitral regurgitation (MR).
Objectives: The aim of the study is to identify if there are specific clinical and echocardiographic criteria that can predict the occurrence of ventricular arrhythmias in patients with mitral valve prolapse.
Methods:We prospectively enrolled 30 consecutive patients with MVP. Clinical examination, echocardiography (standard and speckle tracking) and 24 hours Holter monitoring were performed in all patients. The patients were further divided into 2 groups: arrhythmic MVP (7 patients) and non- arrhythmic MVP (23 patients) based on the presence of complex ventricular arrhythmias on Holter monitoring.
Results: Patients with arrhythmic MVP experienced syncope more frequently compared to the non- arrhythmia group (57 vs 4%, p=0.006). They also had larger left ventricular (LV) end systolic volume (45 ± 8.8 vs 36 ± 8 ml, p=0.023) despite similar LV ejection fraction (EF) and global longitudinal strain (GLS). The arrhythmic MVP patients had wider mitral annular disjunction (7.7 ± 3.8 vs 3.9 ± 3.9 mm, p=0.033).There were no significant difference between the 2 groups regarding the degree of mitral regurgitation, leaflet affection (single or bileaflet) or mitral annular diameters.
Conclusion:Increased left ventricular end systolic volume and the degree of annular disjunction by echocardiography may contribute to the arrhythmic risk in patients with MVP irrespective of the presence and severity of mitral regurgitation.
Keywords
Mitral valve prolapse; ventricular arrhythmias; mitral annular disjunction
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