Omran, M., Zahran, F., Kadry, M., Belal, A., Abd Alsamie, H. (2019). The utility of biomarkers in the discrimination of acute coronary syndrome patients. test, 5(1), 60-74. doi: 10.21608/jbaar.2019.109399
Mohamed M. Omran; Faten M. Zahran; Mohamed Kadry; Arafa A. M. Belal; Hesham S. Abd Alsamie. "The utility of biomarkers in the discrimination of acute coronary syndrome patients". test, 5, 1, 2019, 60-74. doi: 10.21608/jbaar.2019.109399
Omran, M., Zahran, F., Kadry, M., Belal, A., Abd Alsamie, H. (2019). 'The utility of biomarkers in the discrimination of acute coronary syndrome patients', test, 5(1), pp. 60-74. doi: 10.21608/jbaar.2019.109399
Omran, M., Zahran, F., Kadry, M., Belal, A., Abd Alsamie, H. The utility of biomarkers in the discrimination of acute coronary syndrome patients. test, 2019; 5(1): 60-74. doi: 10.21608/jbaar.2019.109399

The utility of biomarkers in the discrimination of acute coronary syndrome patients

Journal of Bioscience and Applied Research
Article 7, Volume 5, Issue 1, March 2019, Pages 60-74    PDF (537.96 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2019.109399
Authors
Mohamed M. Omran* 1; Faten M. Zahran2; Mohamed Kadry3; Arafa A. M. Belal3; Hesham S. Abd Alsamie4
1Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
3Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt
4Clinical Pathology Department, Faculty of Medicine, New Damietta, Al-Azhar University, Egypt
Abstract
Background: The assessment of acute coronary syndrome (ACS) provides useful data not only for identification but also for therapeutic decisions. Objective: To develop a score based on cardiac biomarker for the early diagnosis of ACS patients. Methods: Serum concentrations of myeloperoxidase (MPO) and monocyte chemoattractant protein-1 (MCP-1) beside cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) were measured in a total 200 chest pain patients represented in two groups (estimation and validation). The diagnostics value of biomarkers for discriminating ACS patients was evaluated by area under the receiver-operating characteristic curve (AUC). Multivariate discriminant analysis (MDA) was used to create a predictive score. Results: A novel score depends on a combination of cTnI, CK-MB, MPO, and MCP-1 produces AUCs of 0.93 for discriminating ACS patients and 0.90 for acute myocardial infarction (AMI). This score correctly classified 95% of ACS patients and 93% of AMI patients with good efficiencies were 88.3% and 81%; respectively. This score had similar results in the validation study. Conclusion: Four biomarkers in combination yield a novel score to help in the early and safe prediction of ACS and AMI.
Keywords
Myeloperoxidase; Monocyte chemoattractant protein-1, Acute coronary syndrome
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