Atiba, A., Abdo, W., Madkour, F. (2013). INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS. test, 11(1), 79-90. doi: 10.21608/kvmj.2013.110166
Ayman Atiba; Walied Abdo; Fedekar F. Madkour. "INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS". test, 11, 1, 2013, 79-90. doi: 10.21608/kvmj.2013.110166
Atiba, A., Abdo, W., Madkour, F. (2013). 'INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS', test, 11(1), pp. 79-90. doi: 10.21608/kvmj.2013.110166
Atiba, A., Abdo, W., Madkour, F. INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS. test, 2013; 11(1): 79-90. doi: 10.21608/kvmj.2013.110166

INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS

Kafrelsheikh Veterinary Medical Journal
Article 5, Volume 11, Issue 1, April 2013, Pages 79-90    PDF (584.23 K)
Document Type: Original Article
DOI: 10.21608/kvmj.2013.110166
Authors
Ayman Atiba* 1; Walied Abdo2; Fedekar F. Madkour3
1Departments of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.
2Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.
3Marine Science Department, Faculty of Science, Port Said University, Egypt.
Abstract
Objectives:To investigate the feasibility and safety of brown algae (Cystoseira myrica) extract in the improvement of wound healing process.
Materials and Method:Full thickness excision wounds (1.5 x 1.5 cm) were created under general anesthesia on the back of the rats. These rats were divided into two groups; control group (Group C) and brown algae extract topical application group (Group B). Each wound area was measured on days 0, 3, 6, 9, 12, 15 and 18 post-wounding. On day 18 post-wounding, animals were sacrificed.  Quantification of granulation tissue and their biochemical and histological aspects in control as well as treated groups were estimated.
Results: Brown algae extract showed significant increase in wound contraction and formation of scars on days 9, 12, 15 and18 post wounding (p < 0.001). Histologically, extracellular matrix deposition and epithelialization were promoted in Group B.
Conclusion: The present results suggest that brown algae (Cystoseira myrica) extract can effectively improve wound healing in a full-thickness skin wound model. Use of brown algae (Cystoseira myrica) extract might therefore facilitate development and improvement of wound healing treatments in future.
Keywords
Brown algae; Cystoseira myrica; Skin; Wound healing
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