(2013). Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II). test, 56(2), 141-153. doi: 10.21608/ejchem.2013.1104
. "Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)". test, 56, 2, 2013, 141-153. doi: 10.21608/ejchem.2013.1104
(2013). 'Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)', test, 56(2), pp. 141-153. doi: 10.21608/ejchem.2013.1104
Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II). test, 2013; 56(2): 141-153. doi: 10.21608/ejchem.2013.1104

Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)

Egyptian Journal of Chemistry
Article 3, Volume 56, Issue 2, April 2013, Pages 141-153    PDF (508.09 K)
DOI: 10.21608/ejchem.2013.1104
Abstract
THREE analogs of Bradykinin, (Cys6,8) BK, (Cys2,5) BK and (Cys1,9) BK were synthesized by modified solid phase peptide synthesis with the application of microwave energy. The effect of the replacement of; Ser6 and Phe8 by Cys6,8, Pro2 and Phe5 by Cys2,5,and Arg1,9 by Cys1,9 on the biological activity of bradykinin was investigated. A continued work of a previously done study includes synthesis of three BK analogs, (Lys1) BK, (Lys9) BK and (Lys1, 9) BK, using the modified solid phase peptide synthesis with microwave energy. The six analogues have been tested in vitro for their effect on heart rate and in isolated organ for the arterial pressure of rats.
Keywords
Bradykinin; Modified solid phase peptide synthesis and Microwave energy
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