Hassan, A., Howsawi, B., Awwas, M., Alzein, Z., Alanazi, F., Faqehi, H., Mugharbal, E., Alrehaili, M., Alshehri, K., Buzeid, R., Alharbi, K., Alrzoq, M. (2018). The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation. test, 70(5), 771-776. doi: 10.12816/0043981
Alruwaili Fahad Saleh Hassan; Basmeh Mohammed I Howsawi; Muayad Youssof Al Awwas; Zainab Hassan Alzein; Farhan Musafiq Alanazi; Haya Hussain Faqehi; Ehab Osama Mugharbal; Muath Ayidh Alrehaili; Khalid Ahmed Abdullah Alshehri; Reem Adel Buzeid; Khalid Jazi Alharbi; Musab Abdulrahman Alrzoq. "The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation". test, 70, 5, 2018, 771-776. doi: 10.12816/0043981
Hassan, A., Howsawi, B., Awwas, M., Alzein, Z., Alanazi, F., Faqehi, H., Mugharbal, E., Alrehaili, M., Alshehri, K., Buzeid, R., Alharbi, K., Alrzoq, M. (2018). 'The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation', test, 70(5), pp. 771-776. doi: 10.12816/0043981
Hassan, A., Howsawi, B., Awwas, M., Alzein, Z., Alanazi, F., Faqehi, H., Mugharbal, E., Alrehaili, M., Alshehri, K., Buzeid, R., Alharbi, K., Alrzoq, M. The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation. test, 2018; 70(5): 771-776. doi: 10.12816/0043981

The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation

The Egyptian Journal of Hospital Medicine
Article 11, Volume 70, Issue 5, January 2018, Pages 771-776    PDF (353.78 K)
Document Type: Original Article
DOI: 10.12816/0043981
Authors
Alruwaili Fahad Saleh Hassan1; Basmeh Mohammed I Howsawi2; Muayad Youssof Al Awwas3; Zainab Hassan Alzein4; Farhan Musafiq Alanazi1; Haya Hussain Faqehi5; Ehab Osama Mugharbal6; Muath Ayidh Alrehaili7; Khalid Ahmed Abdullah Alshehri8; Reem Adel Buzeid9; Khalid Jazi Alharbi7; Musab Abdulrahman Alrzoq
1Aljouf University
2King Abdulaziz Hospital
3Alsalmanyiah PHC In Alahsa
4Medical University of Warsaw, Aljouf University
5Jazan University
6Ohud Hospital
7Qassim University
8Al Imam Mohammed Bin Saud Islamic University
9Imam Abdulrahman Bin Faisal University
Abstract
Background: Congenital heart defects (CHDs) are significant drivers of mortality and morbidity in children, folic acid supplementation for the pregnant month during or before delivery is said to influence risk reduction of congenital heart defects (CHDs). However, there are controversial claims and the hypothesis is concluded from limited epidemiologic studies. Aim of the Study: Conduct a systematic review and meta-analysis of published studies to reliably evaluate the correlation between Folic acid or multivitamins containing FA supplementation taken during pregnancy and the risk of CHDs. Methods: A systematic review and meta-analysis was conducted. PUBMED and EMBASE were searched to identify prospective cohort and case-control studies that had reported on the association between 1960 and 2017.Studies conducted in primarily high-risk populations (Case control and cohort studies) while participants in randomized controlled trials were excluded.
Results: The search yielded 10 studies published between 2000 and 2013 enrolling 13126 female participants. These studies included only one cohort study, and nine case-control studies. The overall results of this meta-analysis provide evidence that maternal folate supplementation is associated with a significantly decreased risk of CHDs (RR = 0.69, 95% CI: 0.54–0.84). Statistically significant heterogeneity was detected (Q = 79.43, P < 0.001, I2 = 70.2%).
Conclusion: FA supplementation during pregnancy significantly decreases the risk of CHDs in newborns.
Keywords
Folic acid; Pregnancy; congenital heart defects; Maternal Folic Acid Supplementation
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