abdel hamid, Y., Abdel Moniem, A., Khalifa, N., Elsafy, U. (2023). assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).. test, 29(1.2), 9-16. doi: 10.21608/zumj.2020.31650.1867
Yasser mustafa abdelazim abdel hamid; Ahmed Mohammed Abdel Moniem; Naglaa Khalifa; usama Roshdy Elsafy. "assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).". test, 29, 1.2, 2023, 9-16. doi: 10.21608/zumj.2020.31650.1867
abdel hamid, Y., Abdel Moniem, A., Khalifa, N., Elsafy, U. (2023). 'assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).', test, 29(1.2), pp. 9-16. doi: 10.21608/zumj.2020.31650.1867
abdel hamid, Y., Abdel Moniem, A., Khalifa, N., Elsafy, U. assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).. test, 2023; 29(1.2): 9-16. doi: 10.21608/zumj.2020.31650.1867

assessment of The Role of Interleukin 6, C-Reactive Protein and high sensitive C-Reactive Protein in the diagnosis of early onset neonatal sepsis (A clinical and laboratory approach).

Zagazig University Medical Journal
Article 547, Volume 29, Issue 1.2, January 2023, Pages 9-16    PDF (269.35 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2020.31650.1867
Authors
Yasser mustafa abdelazim abdel hamid* 1; Ahmed Mohammed Abdel Moniem2; Naglaa Khalifa3; usama Roshdy Elsafy2
1Department of pediatrics, Zagazig University hospitals, Egypt.
2pediatric-medicine-zagazig university-zagazig-Egypt
3Faculty of Medicine, Zagazig University, Department of Clinical Pathology, Sharkia, Egypt
Abstract
Abstract

Background: Bacterial sepsis is a life threatening crisis with high mortality and morbidity in neonates, Reliable marker is needed for the diagnosis of neonatal sepsis so that early treatment can be initiated. C-reactive protein (CRP), IL-6 can be used as Reliable markers for the diagnosis of neonatal sepsis so that early treatment can be initiated.
Aim of the work: to detect the levels of IL-6, CRP and HS-CRP in clinically suspected cases of neonatal sepsis and evaluation and analysis of these parameters as early markers of neonatal sepsis.
Patients and methods: A prospective cohort study was conducted on 60 neonates at neonatal intensive care unit of pediatric department and clinical pathology department at Zagazig university hospitals.
Results: IL-6 at a cut off value of 187.5Pg/ml had sensitivity of 87.5% and specificity of 63.6% with a negative predictive value of 93.3%. HS-CRP at a cut off value of 3.3 Mg/L had a higher sensitivity but a lower specificity at 100% and 47.7% repectively. CRP showed higher specificity than HS-CRP and IL-6 with 61.7% with a negative predictive value of 90%. A combination of IL-6 and CRP showed improvement of sensitivity to 100% and a negative predictive value of 100% and is more cost effective than the combination of IL-6 and HS-CRP which showed similar sensitivity and negative predictive value but showed less specificity
Conclusion: a combination of IL-6 and HS-CRP would be a sensitive test for early diagnosis of neonatal sepsis at a sensitivity of 100% and a similar NPV,
Keywords
Key words: neonatal sepsis; CRP; HS-CRP; IL-6; NPV. Early diagnosis
Statistics
Article View: 261
PDF Download: 127