Shabaka, F., Al Badawy, N., Darwish, H., Salah, B. (2020). Evaluation of the molecular marker TOX protein in diagnosis of early stages of mycosis fungoides. test, 1(2), 46-54. doi: 10.21608/jram.2020.19493.1018.
Fatma Shabaka; Nafissa Al Badawy; Hanan Darwish; Basem Salah. "Evaluation of the molecular marker TOX protein in diagnosis of early stages of mycosis fungoides". test, 1, 2, 2020, 46-54. doi: 10.21608/jram.2020.19493.1018.
Shabaka, F., Al Badawy, N., Darwish, H., Salah, B. (2020). 'Evaluation of the molecular marker TOX protein in diagnosis of early stages of mycosis fungoides', test, 1(2), pp. 46-54. doi: 10.21608/jram.2020.19493.1018.
Shabaka, F., Al Badawy, N., Darwish, H., Salah, B. Evaluation of the molecular marker TOX protein in diagnosis of early stages of mycosis fungoides. test, 2020; 1(2): 46-54. doi: 10.21608/jram.2020.19493.1018.

Evaluation of the molecular marker TOX protein in diagnosis of early stages of mycosis fungoides

Journal of Recent Advances in Medicine
Article 1, Volume 1, Issue 2, July 2020, Pages 46-54    PDF (7.14 M)
Document Type: Original Article
DOI: 10.21608/jram.2020.19493.1018.
Authors
Fatma Shabaka1; Nafissa Al Badawy2; Hanan Darwish3; Basem Salah* 4
1Dermatology and Venerology Department, Faculty of Medicine for girls, Cairo, Al- Azhar University, Egypt.
2Pathology Department, Faculty of Medicine Ain shams university, Cairo, Egypt.
3Dermatology and Venerology Department, Faculty of Medicine for girls, Cairo, Al- Azhar University, Egypt.
4Dermatology and venerology Department, nuclear martial authority, Cairo,Egypt.
Abstract
Background: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL).
Differentiation of MF especially early stages (eMF) from its benign mimickers is important to ensure proper
management. TOX is a critical regulator of early T-cell development in the thymus that is considered as a useful
marker for MF diagnosis and prognosis.
Objective: The aim of the current study was to evaluate the ability of molecular marker TOX protein in diagnosis
of eMF, and its ability to differentiate eMF from similar benign inflammatory skin diseases (BIDs).
Methodology: This is a case control study and was carried out on 60 subjects; 20 patients as eMF, 20 patients as
(BIDs) and 20 normal skin specimens as control cases. The diagnosis was established after clinicopathological
correlation. Immunohistochemistry (IHC) was done for MF, BIDs and normal skin cases for TOX and CD4 IHC
stains.
Results: TOX expression showed a significant positive expression in MF cases compared to BIDs and control
groups, with 100% sensitivity and 95% specificity. The pattern of TOX IHC stain in MF was diffuse, while in BIDs
was focal.
Conclusion: TOX might be considered a diagnostic marker for eMF that can differentiate eMF from BIDs
mimickers.
Keywords
Cutaneous T cell lymphoma; mycosis fungoides; early mycosis fungoide; benign inflammatory skin diseases; Thymocytes selection associated HMG-box
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