Study of the biochemical, histological and cytogenetic effects of two different energy drinks (EDs); Red bull and power horse; on brain of adult male Albino rats and to determine the possible protective role of omega-3 on the adverse effects of EDs". | ||
| Journal of Recent Advances in Medicine | ||
| Article 2, Volume 1, Issue 2, July 2020, Pages 55-66 PDF (2.37 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jram.2019.19793.1019 | ||
| Authors | ||
| Wesam Abdelwahab* 1; Samah Elsayed1; Abla Afify1; Amira Mohammed2; Rehab Abd AlRahman3 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| 2Cell Biology Department, National Research Center in Dokki, Cairo, Egypt. | ||
| 3Histology Department, Faculty of Medicine for Ggirls, Cairo, Al-Azhar University, Egypt. | ||
| Abstract | ||
| Background: Energy drinks (EDs) became a worldwide phenomenon and popular especially among young adult and the brain is one of the most vulnerable organs to toxicity. Objective: This work aimed to study the sub chronic effect of consumption of two different popular energy drinks (power horse and red bull) on the brain of adult male albino rats through biochemical, histological and cytogenetic parameters, and to determine the possible protective role of Omega-3 on the adverse effects of EDs. Also, to determine the effects of EDs withdrawal (recovery period). Methodology: Forty-eight adult male albino rats were divided into 8 groups; control, omega 3, RB, PH, each of EDs combined with omega 3 and after 2 weeks of withdrawal. Blood samples, brains and femora from the rats were obtained for biochemical, histological and cytogenetic evaluation. Results: The studied EDs resulted in elevation of the oxidative stress marker malondialdehyde, structural and numerical chromosomal aberrations. While they decreased the antioxidant markers (catalase and Superoxide dismutase), acetylcholinesterase activity, total content of DNA and RNA in brain tissue and the mitotic index with disturbance in the normal histology of the brain. Either treatment with omega 3 or EDs withdrawal improve these changes with better effect to omega 3. Conclusion: EDs are toxic to the brain. Omega 3 or EDs withdrawal can ameliorate this toxicity with better effect to omega 3. Therefore, strict control of EDs consumption is urgently needed | ||
| Keywords | ||
| Energy drinks; power horse; red bull; brain toxicity | ||
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