Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection | ||
| International Journal of Medical Arts | ||
| Article 25, Volume 2, Issue 4, October 2020, Pages 854-859 PDF (2.12 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2020.23053.1138 | ||
| Authors | ||
| Ibrahim Anam Ezzelregal* 1; Fathya Mostafa Elraie1; Khalid Elmola1; Mostafa Mohamed Shaqueer2 | ||
| 1Department of Hepatology, Gastroenterology and Infectious Disease, Damietta Faculty of Medicine, Al-Azhar University, Egypt. | ||
| 2Department of Radiology, Damietta Faculty of Medicine, Al-Azhar University, Egypt. | ||
| Abstract | ||
| Background: Achievement of sustained virological response [SVR] and improvement of hepatic fibrosis are the essential goals for therapy of chronic hepatitis C [CHC] with direct acting antivirals [DAAs] therapy. Early detection and management of hepatic fibrosis can significantly improve the prognosis of CHC in clinical practice. Aim of the work: To assess the effect of successful DAAs therapy on liver stiffness in patients with CHC. Methods: This study included 100 patients with chronic HCV-related liver disease. All were treated with Sofosbuvir-based regimen for 12 weeks on outpatient base. HCV treatment applied according to the protocol designed by the Egyptian National Committee for Control of Viral Hepatitis. Follow up continued for 12 weeks [after the end of treatment [EOT]] to estimate effect of successful DAAS therapy on liver stiffness using Shear Wave Elastography [SWE], aminotransferase-to platelet ratio index [APRI] and Fib-4 score before initiation of antiviral therapy, at end of treatment [EOT] and 12 weeks after EOT [SVR12]. Results: Platelets significantly increased, ALT and AST decreased and mean values of APRI, Fib-4 score and Liver stiffness assessment were significantly reduced in all patients at SVR12. Hemoglobin levels significantly reduced in patients receiving ribavirin 12 weeks after EOT. Conclusions: Elimination of HCV after successful DAAS treatment was associated with a significant improvement of the liver stiffness at both EOT and 12 weeks afterwards EOT as evidenced by SWE, Fib-4 score and APRI index | ||
| Keywords | ||
| Direct acting antivirals; Elastography; Hepatitis C Virus; Liver fibrosis; sustained virological response | ||
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