Haggag, O., Mahmoud, N., Khodeary, M., Sharawy, N. (2020). Chronic Toxic Effect of Triclosn on Reproductive System of Albino Rats.. test, 37(3), 691-709. doi: 10.21608/bmfj.2020.112907
Ola Haggag; Nermeen Mahmoud; Mohammed Khodeary; Nesma Sharawy. "Chronic Toxic Effect of Triclosn on Reproductive System of Albino Rats.". test, 37, 3, 2020, 691-709. doi: 10.21608/bmfj.2020.112907
Haggag, O., Mahmoud, N., Khodeary, M., Sharawy, N. (2020). 'Chronic Toxic Effect of Triclosn on Reproductive System of Albino Rats.', test, 37(3), pp. 691-709. doi: 10.21608/bmfj.2020.112907
Haggag, O., Mahmoud, N., Khodeary, M., Sharawy, N. Chronic Toxic Effect of Triclosn on Reproductive System of Albino Rats.. test, 2020; 37(3): 691-709. doi: 10.21608/bmfj.2020.112907

Chronic Toxic Effect of Triclosn on Reproductive System of Albino Rats.

Benha Medical Journal
Article 19, Volume 37, Issue 3, September 2020, Pages 691-709    PDF (963.03 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.112907
Authors
Ola Haggag; Nermeen Mahmoud; Mohammed Khodeary; Nesma Sharawy
Department of Forensic medicine and Clinical Toxicology, Benha faculty of medicine, Benha University, Egypt
Abstract
Background: Triclosan (TCS) is a widely used antiseptic compound that has been added to personal care products. Triclosan is absorbed through mucous membranes of the oral cavity and gastrointestinal tract after oral exposure and through the skin after dermal exposure. It is suspected to be a potential reproductive toxicant.  Aim: assessment of the chronic toxicity of triclosan on testes and ovaries of normal adult albino rats through measuring the level of hormones as testosterone, estrogen ,FSH and LH and assessment of histopathological and ultrastructural changes in testes and ovaries . Methods : A total of 80 normal adult albino rats (40males and 40 females) were used ,the animals were divided into 8 equal groups (10 rats per each group) as follows: Group-I (Male Control Group),Group-II (Female Control Group),Group-III (Vehicle-Treated, Acacia GumTreatedMale Group),Group-IV (Vehicle-Treated, Acacia GumTreatedFemale Group),Group-V (TriclosanorallyTreatedMale Group),Group-VI (Triclosan orally TreatedFemale Group), In Group-VII (Triclosandermally exposed male Group , group VIII(  Triclosan dermally exposed Female Group), the groups received doses of triclosan(For oral groups:435 mg/kg body weight, For skin exposed groups: 600 mg/kg body weight) for twelve weeks . Results: Decreased levels of measured hormones, Low sperms count and motility, histopathological and ultrastructural changes in testes and ovaries in oral and dermal exposed groups.Conclusion: Triclosan caused low levels of sex hormones  as testosterone, estrogen, FSH and LH, It affected sperms count and motility and It caused histopathological and ultrastructural changes in testes  and ovaries.
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