NASR, M., ABD EL HAMID, A., ALY, N., OMAR, G., BARAKAT, A., AHMED, K., YOUSSIF, S., RASHED, G. (2020). EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE. test, 50(2), 293-299. doi: 10.21608/jesp.2020.113050
MONA E. NASR; ATEF H. ABD EL HAMID; NAGWA S. M. ALY; GHADA H. OMAR; ASHRAF M. A. BARAKAT; KAWKAB A. AHMED; SAFAA H. YOUSSIF; GEHAN A. RASHED. "EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE". test, 50, 2, 2020, 293-299. doi: 10.21608/jesp.2020.113050
NASR, M., ABD EL HAMID, A., ALY, N., OMAR, G., BARAKAT, A., AHMED, K., YOUSSIF, S., RASHED, G. (2020). 'EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE', test, 50(2), pp. 293-299. doi: 10.21608/jesp.2020.113050
NASR, M., ABD EL HAMID, A., ALY, N., OMAR, G., BARAKAT, A., AHMED, K., YOUSSIF, S., RASHED, G. EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE. test, 2020; 50(2): 293-299. doi: 10.21608/jesp.2020.113050

EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE

Journal of the Egyptian Society of Parasitology
Article 10, Volume 50, Issue 2, August 2020, Pages 293-299    PDF (1.21 M)
Document Type: Original Article
DOI: 10.21608/jesp.2020.113050
Authors
MONA E. NASR1; ATEF H. ABD EL HAMID2; NAGWA S. M. ALY3; GHADA H. OMAR3; ASHRAF M. A. BARAKAT4; KAWKAB A. AHMED5; SAFAA H. YOUSSIF3; GEHAN A. RASHED3
1Department of Parasitology, Faculty of Medicine, Benha University, Egypt
2Faculty of Medicine, Benha University, Egypt
3Department of Parasitology
4Department of Zoonotic Diseases
5Department of Pathology
Abstract
Toxoplasma gondii is an opportunistic protozoan that causes a devastating disease in immunocompromised
individuals and congenitally infected neonates or children. This study evaluated the
efficacy of early Azithromycin treatment of Toxoplasma gondii infected mice with cystogenic Me
49 non-virulent strain. Fifty laboratory-bred female Swiss albino mice were divided into 5 groups:
G1: Non-Infected, G2: Infected non-treated, G3: Infected and treated by Azithromycin 200
mg/kg at 4th day post-infection for 3 days, G4: Infected and treated by Azithromycin 200mg/kg at
4th day post-infection for 10 days & G5: Infected and treated by Spiramycin 200mg\kg at 4th day
post-infection for 2 weeks, brain cysts’ number, size and histopaholoical changes were assessed
after 3 months. Treatment with Azithromycin for 10 days decreased number and size of brain
cysts by 70% & 40% respectively without significant difference with Spiramycin treated mice
that caused reduction by 74% & 50% respectively. Azithromycin treatment for 3 days caused the
least reduction by 51% & 21% respectively and Azithromycin treatment for 10 days decreased
the histo-pathological changes in cerebral toxoplasmosis. Azithromycin treatment started at 4th
day post-infection was effective than Spiramycin against T. gondii infection with a significant effect
on cysts count and size and brain pathological changes. Azithromycin treatment for 10 days
gave better effect than 3 days.
Keywords
Mice; Azithromycin; Spiramycin; Toxoplasma gondii; Treatment
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