REPURPOSING OF ANTI-MALARIAL SYNRIAMTM AND TESTING ITS EFFICACY AGAINST EGYPTIAN STRAIN OF SCHISTOSOMA HAEMATOBIUM | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 16, Volume 50, Issue 2, August 2020, Pages 344-352 PDF (1.31 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2020.113056 | ||
| Authors | ||
| HEBAT-ALLAH S.A. YOUSOF1; SHAIMAA H. EL-SAYED2; EMAN ELFAR3; MONA M. KHATER1 | ||
| 1Department of Medical Parasitology | ||
| 2Faculty of Medicine, Cairo University, Cairo, Department of Medical Parasitology | ||
| 3Department of Public Health and Community Medicine | ||
| Abstract | ||
| Trials for discovering an anti-malarial drug, which can compete Schistosomal infection in co-endemic areas, are ongoing. Some preliminary studies were done on Synriam (SYN), antimalarial drug combination (arterolane maleate and piperaquine phosphate) released from Ranbaxy, to test its anti-schistosomal effect. But, in vitro incubation of SYN with different Schistosoma haematobium stages was not fully assessed. This study determined the antischistosomal in vitro effect of SYN on adult and juvenile stages of Schistosoma haematobium- Egyptian strain. Adult and juvenile worms were incubated with ascending concentrations of SYN and with praziquantel as positive control. Viability, survival, morphological and ultrastructural changes were assessed at different time points. Higher concentrations of 60, 80 μg/ml showed rapid and lethal effects on adult and juvenile stages of both species, with prominent ultrastructural alterations. Concentrations of (10, 20, & 40μg/ml) showed mild to moderate effect on adult schistosomes. On contrarily to praziquantel, larval immature stages responded significantly and rapidly to low concentration of SYN with 100% death rate. The present findings were consistent with the evaluation of anti-schistosomal therapeutic effect of SYN to be utilized in malaria co-endemic areas. | ||
| Keywords | ||
| Anti-schistosomal, In-vitro; Schistosoma haematobium; Schistosoma mansoni; Synriam; Drug repurposing | ||
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