Assessment of Follicular-Fluid Neurotrophin Levels as Predictor for Ovarian Reserve in Women Undergoing Assisted Reproductive Technology for Different Etiologies of Infertility | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 11, Volume 70, Issue 4, January 2018, Pages 584-593 PDF (411.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2018.11365 | ||
| Authors | ||
| Magdy H. Koleib; Fekrya A. Salama; Nashwa E. Hassan; Hanan S. Mohammed* | ||
| Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: brain-derived neurotrophic factor (BDNF) is a27-kDa polypeptide that belongs to the neurotrophin family binding with high-affinity protein kinase receptors (Trk) and the unselective p75NGFR receptor. The BDNF gene has a complex structure with multiple regulatory elements and four promoters that are differentially expressed in the central or peripheral tissue. Aim of the Work: this study aimed to detect affection of follicular fluid neurotrophin level in different types of infirtility and its using as peredictor for ovarian reserve. Patients and Methods: this crosssectional study was carried out in Ain Shams University, Maternity Hospitals Assisted Reproductive Technology Unit (ART unit) in the period from Septemper2016 to June 2017. Results: the present study showed a cut-off value of BDNF for the patients who underwent this study was 2.7 pg/ml with sensitivity of 74.2%, specificity 95.5%, PPV 85.2% and NPV 91.4%. Conclusion: FF-BDNF measurement on the d-OPU in women with different types of infertility underwent COH for IVF-ET, had positive correlation with ovarian reserve and positive predictor of pregnancy which occurred in 25.8% of cases. Recommendations: BDNF has positive correlation with ovarian reserve and positive correlation with pregnancy outcome so we recommend to measure serum BDNF before starting IVF cycle as predictive factore and cost effective. | ||
| Keywords | ||
| follicular-fluid neurotrophin; Predictor; ovarian reserve; art; Infertility | ||
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