Ahmed, S., Ahmed, N., Hassanein, K., Salah EL-Deen, E. (2020). Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast. test, 24(3), 81-87. doi: 10.21608/smj.2020.37789.1178
Sheren FM Ahmed; Nagwa Abd El-Sadek Ahmed; Kamal A A Hassanein; Eman Muhammad Salah EL-Deen. "Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast". test, 24, 3, 2020, 81-87. doi: 10.21608/smj.2020.37789.1178
Ahmed, S., Ahmed, N., Hassanein, K., Salah EL-Deen, E. (2020). 'Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast', test, 24(3), pp. 81-87. doi: 10.21608/smj.2020.37789.1178
Ahmed, S., Ahmed, N., Hassanein, K., Salah EL-Deen, E. Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast. test, 2020; 24(3): 81-87. doi: 10.21608/smj.2020.37789.1178

Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Invasive Ductal Carcinoma of the Breast

Sohag Medical Journal
Article 12, Volume 24, Issue 3, July 2020, Pages 81-87    PDF (1007.26 K)
Document Type: Original Article
DOI: 10.21608/smj.2020.37789.1178
Authors
Sheren FM Ahmed1; Nagwa Abd El-Sadek Ahmed* 2; Kamal A A Hassanein3; Eman Muhammad Salah EL-Deen4
1Pathology department, Faculty of medicine, Sohag university
2Department of Pathology-Faculty of Medicine-Sohag Univeristy-Egypt
3Depatyment of General Surgery Faculty of medicine Sohag Univetsity
4Pathology Department, Faculty of Medicine, Sohag University
Abstract
Abstract

Background and Aim: VCAM-1 (CD106) expressed mainly on activated endothelial cells in response to pro-inflammatory cytokines. Recent evidences suggest that it is closely correlated with tumor formation, angiogenesis and cancer progression. The aim of the current study was to evaluate expression status of VCAM-1 in mammary invasive ductal carcinoma (IDC), and to correlate its expression with some known clinicopathological data.

Methods: Formalin-fixed paraffin embedded tissue blocks of 58 specimens of IDC were evaluated for VCAM-1 expression by immunohistochemistry (IHC). Correlation of VCAM-1 expression with different clinicopathological data was measured statistically.

Results: Up-regulation of VCAM-1 expression was frequently observed in less differentiated tumors and within advanced stages with poor Nottingham prognostic index (NPI). VCAM-1 overexpression was significantly associated with the presence of lymph node metastasis (LNM), lymphovascular invasion (LVI), and prominent lymphocytic infiltration. There was no significant association of VCAM-1 expression with patients' age, tumor laterality, tumor size, muscle or skin invasion, and presence of in situ component.

Conclusion: VCAM-1 molecule could promote LVI and LNM. VCAM-1 is a potential independent prognostic factor for breast carcinoma.
Keywords
VCAM-1; Breast carcinoma; IDC; CAMs; Tumor progression
Supplementary Files
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