Muzaffar, I., Boundaqji, K., Khatib, H., Almozayin, R., Halawani, M., Abumohssin, A., Gul, B., khan, M., ALhboob, A., Alharbi, F., Mohmmad, M. (2018). An Overview of the Most Common Enzyme Defect, Glucose-6-Phosphate-Dehydrogenase Deficiency. test, 70(1), 102-108. doi: 10.12816/0042970
Ibrahim Hussain Muzaffar; Khaled Rashad Boundaqji; Hazim Abdulkarim Khatib; Ruqayah Taqi Almozayin; Mahmoud Shehab Halawani; Abdulmalik Ghassan Abumohssin; Bayan Khalid Sabb Gul; Mohibullah Noorunnabi khan; Ayman Ali ALhboob; Faris Abdullah Alharbi; Mona Eada Khalfe Mohmmad. "An Overview of the Most Common Enzyme Defect, Glucose-6-Phosphate-Dehydrogenase Deficiency". test, 70, 1, 2018, 102-108. doi: 10.12816/0042970
Muzaffar, I., Boundaqji, K., Khatib, H., Almozayin, R., Halawani, M., Abumohssin, A., Gul, B., khan, M., ALhboob, A., Alharbi, F., Mohmmad, M. (2018). 'An Overview of the Most Common Enzyme Defect, Glucose-6-Phosphate-Dehydrogenase Deficiency', test, 70(1), pp. 102-108. doi: 10.12816/0042970
Muzaffar, I., Boundaqji, K., Khatib, H., Almozayin, R., Halawani, M., Abumohssin, A., Gul, B., khan, M., ALhboob, A., Alharbi, F., Mohmmad, M. An Overview of the Most Common Enzyme Defect, Glucose-6-Phosphate-Dehydrogenase Deficiency. test, 2018; 70(1): 102-108. doi: 10.12816/0042970

An Overview of the Most Common Enzyme Defect, Glucose-6-Phosphate-Dehydrogenase Deficiency

The Egyptian Journal of Hospital Medicine
Article 18, Volume 70, Issue 1, January 2018, Pages 102-108    PDF (275.97 K)
Document Type: Original Article
DOI: 10.12816/0042970
Authors
Ibrahim Hussain Muzaffar1; Khaled Rashad Boundaqji2; Hazim Abdulkarim Khatib3; Ruqayah Taqi Almozayin2; Mahmoud Shehab Halawani4; Abdulmalik Ghassan Abumohssin3; Bayan Khalid Sabb Gul1; Mohibullah Noorunnabi khan2; Ayman Ali ALhboob5; Faris Abdullah Alharbi6; Mona Eada Khalfe Mohmmad7
1Umm Alqura University
2Ibn Sina National College
3King Abdulaziz University
4Batterjee Medical College for Sciences and Technology
5Taiz University
6University of Gezira
7Al Furat University
Abstract
Background: Glucose-6-Phosphate-Dehydrogenase (G6PD) deficiency is the most common enzyme deficiency globally and is more remarkable in certain parts of the world which had high malaria prevalence in the past. It is an X-linked genetically inherited disorder, where the first presentation can be neonatal jaundice. There are over 300 variants of this disorder based upon the genetics. Although the morbidity and mortality is not very high, the deficiency can be more appropriately managed by proper preventive methods which include screening and avoidance of trigger. Also prompt management of acute hemolysis can save a child from many complications.            
Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE from January 1987 to March 2017. The following search terms were used: G6PD deficiency, prevalence of G6PD, genetics of G6PD deficiency, management and diagnosis of G6PD
Aim of the work: this study  aimed to understand about the etiology, pathophysiology and study various lines of prevention and management of G6PD deficiency in pediatric age group.
Conclusion: proper preventive and treatment methods can avoid negative effects on the child’squality of life andreduce morbidity and mortality, therefore the child’s care takers must be well informed.  
Keywords
G6PD deficiency; prevalence of G6PD; genetics of G6PD deficiency; management and prevention of G6PD; diagnosis of G6PD
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