EFFECT OF AGE ON PHARMACOKINETICS OF DANOFLOXACIN IN EGYPTIAN BUFFALO CALVES | ||
| Kafrelsheikh Veterinary Medical Journal | ||
| Article 2, Volume 5, Issue 1, April 2007, Pages 16-31 PDF (752.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/kvmj.2007.115847 | ||
| Authors | ||
| A.A.M. El-Gendy* ; M.A. Tohamy | ||
| Pharmacology Dep., Faculty of Vet . Med., Beni-suef University | ||
| Abstract | ||
| The pharmacokinetic profile of danofloxacin, a fluoroquinolone antibacterial was studied in one, two-months and one year old Egyptian buffalo calves following a single intravenous and intramuscular administration of 1.25 mg kg-1 b.wt. in a cross over study with 15-day wash out period. Drug concentrations in serum were determined by microbiological assay technique. After i.v administration the serum concentration-time curve of danofloxacin was best fitted using two-compartment open model. The drug was rapidly distributed as indicated by short distribution half-lives (t½(α)) of 0.093, 0.117 and 0.194 h in one , two-months and one year old calves, respectively. The elimination half-life was relatively longer in one- and two-months than in one year old calves (t½(β)) 5.802 compared to 4.941 and 3.795 h., respectively. The volumes of distribution at steady-state (Vdss) 1.259, 1.347 and 1.490 L kg-1), total body clearance (ClB)= 0.155, 0.195 and 0.280 L kg-1 h-1) and mean residence time (MRT = 8.127, 6.886 and 5.334 h) were recorded in the three ages, respectively. Ara under the plasma concentration vs. time curve(AUC) was decreased with age 8.564, 6.651 and 4.615 ug ml-1 h-1 in the three ages, respectively). Following intramuscular administration, the absorption half-life (t½(ab)) was 0.421, 0.462 and 0.425 h in the three ages, respectively. The maximum serum concentrations (Cmax) of 0.541, 0.434 and 0.363 ug ml-1 were attained after (tmax) 1.853, 1.810 and 1.712 h in the three ages, respectively. The elimination half-life (t½(el)) and MRT values of danofloxacin were longer in one-month old calves compared to two months and one year old calves. The systemic intramuscular bioavailabilities were 96.672, 98.136 and 94.366 %, while the in-vitro serum protein-binding tendencies were 6.678, 9.176 and 13.572 %, for one, two- months old and one year old calves, respectively. | ||
| Keywords | ||
| danofloxacin; Egyptian buffalo calves | ||
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