Comparison between the Effect of Sildenafil Citrate and Tramadol on Testis and Sperm Quality of Male Rats | ||
| Suez Canal University Medical Journal | ||
| Article 7, Volume 19, Issue 2, October 2016, Pages 167-173 PDF (670.6 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2016.116293 | ||
| Author | ||
| Reham E Masoud* | ||
| Department of Clinical Pharmacology, Faculty of Medicine, Port-Said University, Egypt. | ||
| Abstract | ||
| Background: Nowadays tramadol is becoming abused more popular among teens in most countries worldwide; especially between males and Sildenafil citrate is an oral medication widely used to treat erectile dysfunction and maintains a sufficient erection for satisfactory sexual performance. Aim: The aim of this study is to evaluate and compare the effects of sildenafil citrate and tramadol on the count and morphology of sperms in male rats. Subjects and Methods: The study groups 30 rats divided into 3 groups; normal control, sildenafil citrate treated and tramadol treated group, each group included 10 rats. Serum testosterone was measured by ELISA, sperm count, and morphology was assessed and testicular histopathology was assessed after sacrifice. Results: The present work revealed that treatment with sildenafil citrate and tramadol separately caused a significantly decreased count of sperms and increased abnormal forms as compared to normal (p ≤0.05). There was also a significant decrease in testosterone levels in the tramadol group as compared to both normal and sildenafil treated groups (p ≤0.05). Histopathology of testes showed a reduction of spermatogenic cell number and height and increase interstitial tissue between tubules and in tramadol treated group, loss of most spermatogenic cells, degenerative changes, disturbed architecture of seminiferous tubules, and edema of interstitial tissue. Conclusion: The study concluded that these two drugs impaired testicular function in male rats to varying degrees, tramadol caused more significant impairment in all parameters measured than sildenafil citrate and recommended limiting the use of these two drugs if possible and necessity of designing a national awareness campaign to the public to spotlights on the hazards of tramadol abuse on sexual function. | ||
| Keywords | ||
| sildenafil; tramadol; nitric oxide; testosterone | ||
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