Clinical Significance of Foxp3 Gene Expression in Patients with Lupus Nephritis | ||
| Suez Canal University Medical Journal | ||
| Article 10, Volume 19, Issue 2, October 2016, Pages 193-200 PDF (645.06 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2016.116297 | ||
| Authors | ||
| Amaal Abdel Aleem1; Fadia Attia1; Aziza Omar2; Ranya Hassan* 1 | ||
| 1Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||
| 2Department of Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background: Lupus nephritis (LN) is an inflammation of the kidney that is one of the most seri-ous complications of SLE. Recent studies revealed that the Foxp3 plays an important role in the pathogenesis of SLE. Objectives: To measure Foxp3 mRNA expressions in peripheral blood of patients with active and inactive form of lupus nephritis (LN) versus healthy control subjects and explore its role in disease activity. Subjects and Methods: Real time PCR was used to detect the mRNA expression of Foxp3 by SYBR Green technique in the peripheral blood mononuclear cells (PBMNCs Foxp3) of 24 patients with active lupus nephritis (LN), 10 patients with inactive lupus and 40 healthy subjects. Results: We found that Foxp3 mRNA expression level in both patient groups (n=34) was significantly higher than that in normal control group (n=40), (p < 0.05). The mRNA expression of Foxp3 inactive stage (n=24) was higher than that in inactive stage (n=10), (p < 0.05). Moreover, Foxp3 mRNA level positively correlated with SLEDAI (r=0.592, p | ||
| Keywords | ||
| CD4+CD25+ Tregs; Foxp3 mRNA; SLE | ||
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