elkhalal, D., Alzaghaby, E., attia, H., hamad, S. (2020). hepatoprotective effect of ethanolic extract of Origanum vulgare against doxycycline toxicity.. test, 39(1), 85-90. doi: 10.21608/bvmj.2020.21307.1160
dawlat elkhalal; Ehab Alzaghaby; hosam attia; sherin hamad. "hepatoprotective effect of ethanolic extract of Origanum vulgare against doxycycline toxicity.". test, 39, 1, 2020, 85-90. doi: 10.21608/bvmj.2020.21307.1160
elkhalal, D., Alzaghaby, E., attia, H., hamad, S. (2020). 'hepatoprotective effect of ethanolic extract of Origanum vulgare against doxycycline toxicity.', test, 39(1), pp. 85-90. doi: 10.21608/bvmj.2020.21307.1160
elkhalal, D., Alzaghaby, E., attia, H., hamad, S. hepatoprotective effect of ethanolic extract of Origanum vulgare against doxycycline toxicity.. test, 2020; 39(1): 85-90. doi: 10.21608/bvmj.2020.21307.1160

hepatoprotective effect of ethanolic extract of Origanum vulgare against doxycycline toxicity.

Benha Veterinary Medical Journal
Article 17, Volume 39, Issue 1, September 2020, Pages 85-90    PDF (382.69 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2020.21307.1160
Authors
dawlat elkhalal* 1; Ehab Alzaghaby2; hosam attia3; sherin hamad4
1histology departement -national organization of drug control and research
2histology department -veterinary medicine -Banha university
3histology department veterinary medicine banha university
4histopathology department- national organization of drug control and research
Abstract
The current study evaluates the ameliorative action of Origanumvulgareethanolic extract against the hepatotoxic effects of experimental doxycycline overdose in rats.
Forty male Sprague-Dawley rats (160–200 gm) were divided into four groups: the control group, administered distilled water (10 ml/kg b.w.); group (2) administered doxycycline (39.2 ml/kg b.w.) in distilled water; group (3) administered O. Vulgare ethanolic extract (20 mg/kg b.w.) +doxycycline (39.2 ml/kg b.w.) in distilled water and group (4) administered O. Vulgare ethanolic extract (60 mg/kg b.w.) + doxycycline (39.2 ml/kg b.w.) in distilled water. All rats were administrated once per day for 4weeks.
Doxycycline administrated rats showed alteration in histological structure in the liver as vacuolization, necrosis, inflammation, and sinusoidal dilatations. Also increased Kupffer cells population and congestion and dilatation of central vain with fibrin thrombi filling their lumen were shown.Ultra structurally destructed cell membrane of hepatocyte, Pyknotic and karyolitic nuclei, losses in some cytoplasmic organelles, swollen mitochondria, fragmentation of rER and discarded lysosomes were observed. All of those improved by the ethanolic extract of Origanum vulgare.
Keywords
Rat; Doxycycline; Oregano; Liver; Histology
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