THE ROLE OF SERUM OSTEOPONTIN LEVELS IN EGYPTIAN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 5, Volume 62, Issue 2, September and October 2020, Pages 55-71 PDF (865.11 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2020.118376 | ||
| Author | ||
| Amira Atta | ||
| Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University | ||
| Abstract | ||
| Background: Postmenopausal osteoporosis (PMO) is a debilitating disease induced by estrogen deficiency characterized by bone loss and bone micro-architecture degradation contributing to fragility fractures. Osteopontin (OPN) has been found to be involved in bone turnover by activating the resorption process. Objectives: This study aim to evaluate the relationship between serum OPN levels and bone mineral density (BMD) for identification of female individuals at high risk of osteoporotic fractures. Methods: A total of eighty eight postmenopausal women (PMW) were recruited in this study. Densitometry results addressed cases of the study into 3 groups: thirty with osteoporosis, thirty with osteopenia and twenty eight PMW without complications as a control group. Serum OPN was measured by using Enzyme-Linked immunosorbent assay (ELISA) kits and BMD was obtained at lumbar spine and femoral neck by dual-energy X-ray absorptiometry (DEXA). Results: Osteopontin levels were significantly higher in osteoporotic group compared to osteopenic and control groups (P ˂ 0.001). Negative correlation was found between BMD and OPN in osteoporotic group. By using the Receiver Operating Characteristic (ROC) curve, the cutoff level of ≥ 10.294 ng/mL for OPN was chosen for suggesting osteoporosis which yield a sensitivity of 66.67 % and specificity of 96.43 %. Also, there were a significant increase in serum ALP levels in osteoporotic and osteopenic groups compared to control group while serum Ca failed to show a significant difference between the studied groups. In addition, serum TAC showed a significant decrease in osteoporotic group compared to control group. Conclusion: These findings suggest that the circulating OPN might play role in the pathophysiology of PMO. Its blood concentration can be used as a sensitive monitoring indicator for the early detection of osteoporosis independently of BMD. | ||
| Keywords | ||
| Bone turnover; Estrogen; Osteopontin; Osteoporosis | ||
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