SARR, H., NIANG, A., DIEYE, B., DIOP, A., DIALLO, F., DIAGNE, R., LO, S., DIALLO, K., SOW, A. (2021). Contribution of XPERT MTB/RIF® in the diagnosis of pulmonary tuberculosis in Ziguinchor, Senegal. test, 2(4), 690-696. doi: 10.21608/mid.2020.43109.1063
Habibou SARR; Aissatou Ahmet NIANG; Baidy DIEYE; Amadou DIOP; Fatoumata DIALLO; Rokhaya DIAGNE; Seynabou LO; Kalilou DIALLO; Ahmad Iyane SOW. "Contribution of XPERT MTB/RIF® in the diagnosis of pulmonary tuberculosis in Ziguinchor, Senegal". test, 2, 4, 2021, 690-696. doi: 10.21608/mid.2020.43109.1063
SARR, H., NIANG, A., DIEYE, B., DIOP, A., DIALLO, F., DIAGNE, R., LO, S., DIALLO, K., SOW, A. (2021). 'Contribution of XPERT MTB/RIF® in the diagnosis of pulmonary tuberculosis in Ziguinchor, Senegal', test, 2(4), pp. 690-696. doi: 10.21608/mid.2020.43109.1063
SARR, H., NIANG, A., DIEYE, B., DIOP, A., DIALLO, F., DIAGNE, R., LO, S., DIALLO, K., SOW, A. Contribution of XPERT MTB/RIF® in the diagnosis of pulmonary tuberculosis in Ziguinchor, Senegal. test, 2021; 2(4): 690-696. doi: 10.21608/mid.2020.43109.1063

Contribution of XPERT MTB/RIF® in the diagnosis of pulmonary tuberculosis in Ziguinchor, Senegal

Microbes and Infectious Diseases
Article 12, Volume 2, Issue 4, November 2021, Pages 690-696    PDF (289 K)
Document Type: Original Article
DOI: 10.21608/mid.2020.43109.1063
Authors
Habibou SARR* 1; Aissatou Ahmet NIANG2; Baidy DIEYE2; Amadou DIOP2; Fatoumata DIALLO2; Rokhaya DIAGNE3; Seynabou LO4; Kalilou DIALLO1; Ahmad Iyane SOW2
1Health Sciences Training and Research Unit, University of Ziguinchor, Laboratory and Infectious Diseases Department of the hospital PAIX of Ziguinchor, Senegal
2Faculty of Medicine, Pharmacy and Dentistry, Dakar, Senegal
3Health Sciences Training and Research Unit, University of Thies, Dakar, Senegal
4Health Sciences Training and Research Unit, Saint Louis University, Dakar, Senegal
Abstract
Introduction ─ Multidrug-resistant tuberculosis is resistant to isoniazid and/or rifampicin. It is favored by poverty and infection with the human immunodeficiency virus. This retrospective, descriptive study aimed to determine the contribution of Xpert MTB/RIF® in the diagnosis of multidrug-resistant pulmonary tuberculosis in a semi-urban environment at the Peace Hospital of Ziguinchor in Senegal during the period from April 2015 to August 2019.
Methodology ─ The study is retrospective, descriptive and carried out in the laboratory of Ziguinchor Hospital de la Paix, in southern Senegal, from April 2015 to August 2019. All respiratory specimens were subjected to Ziehl-Neelsen-stained smear microscopy and Xpert MTB/RIF® testing.
Results ─ 180 samples, i.e. 6.4% were microscopy-negative but positive in Xpert MTB/RIF® testing. 32 patients (1%) are infected with rifampicin-resistant M. tuberculosis, against 29% of patients (798/2794) infected with susceptible strains.
Conclusion ─ Tuberculosis is not longer a “disease of the past”. Having a high cost, Xpert MTB/RIF® testing must be associated with microscopy, which remains accessible in semi-urban areas and is easy to perform.
Keywords
tuberculosis; resistance; rifampicin; Xpert MTB/RIF®
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