Abdu, S., Abdulaziz, B., EL Kharbotly, E., Nassief, A. (2020). Assessment of Liver Fibrosis In Non-Alcoholic Fatty Liver Disease Using Real-Time Elastography. test, 37(Special issue (Internal medicine and Hepatology)), 1-11. doi: 10.21608/bmfj.2020.120188
Sabry Abdu; Badawy Abdulaziz; Enas EL Kharbotly; Anwar Nassief. "Assessment of Liver Fibrosis In Non-Alcoholic Fatty Liver Disease Using Real-Time Elastography". test, 37, Special issue (Internal medicine and Hepatology), 2020, 1-11. doi: 10.21608/bmfj.2020.120188
Abdu, S., Abdulaziz, B., EL Kharbotly, E., Nassief, A. (2020). 'Assessment of Liver Fibrosis In Non-Alcoholic Fatty Liver Disease Using Real-Time Elastography', test, 37(Special issue (Internal medicine and Hepatology)), pp. 1-11. doi: 10.21608/bmfj.2020.120188
Abdu, S., Abdulaziz, B., EL Kharbotly, E., Nassief, A. Assessment of Liver Fibrosis In Non-Alcoholic Fatty Liver Disease Using Real-Time Elastography. test, 2020; 37(Special issue (Internal medicine and Hepatology)): 1-11. doi: 10.21608/bmfj.2020.120188

Assessment of Liver Fibrosis In Non-Alcoholic Fatty Liver Disease Using Real-Time Elastography

Benha Medical Journal
Article 1, Volume 37, Special issue (Internal medicine and Hepatology), November 2020, Pages 1-11    PDF (738.22 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.120188
Authors
Sabry Abdu1; Badawy Abdulaziz1; Enas EL Kharbotly1; Anwar Nassief2
1Department of Hepatology, Gastroenterology and infectious diseases, Faculty of Medicine, Benha University, Egypt.
2Department of internal medicine, Damanhour Medical National Institute, Egypt.
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) become a challenge as it`s prevalence, difficulty to diagnose and complex pathogenesis representing about 20% of common liver disorders Patients with NAFLD are at higher risk for adverse outcomes such as cirrhosis, HCC and liver-related mortality. Aim and objectives : We aim to assess the applicability and performance of real-time elastography for the diagnosis of liver fibrosis.Methods: One hundred and thirty subjects attended damanhour medical national institute hepatology and gastroenterology outpatient clinic were divided into two groups; Group (I): Hundred cases having NAFLD by ultrasound, Group (II): thirty healthy subjects as control.Results: Fibrosis stages in NAFLD patients significantly higher than in the control group diagnosed by real time elastrography (P = 0.001). There was an agreement between Realtime Elastrography and FIB-4 index and NAFLD fibrosis score 93% and 86% respectively and diagnostic performance of real time elastrography in advanced liver fibrosis ≥F3 was assessed in comparing with FIB-4 index show sensitivity 90%, specifity 93.3%, PPV 60%, NPV 98.8%, accuracy 93%, AUC0.917, 95%CI 0.81-1.0 and (p = 0.001). Conclusion : Real time elastography may be useful in diagnosis of fibrosis in non-alcoholic fatty liver disease.
Keywords
Non-alcoholic fatty liver disease (NAFLD); Hepatocellular carcinoma (HCC); Non-alcholic steato hepatitis (NASH); Real time Elastrography(RTE
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