Synthesis, Characterization and Anticancer Activity of Some Benzothiazole and Thiazole Derivatives | ||
| Journal of Advanced Pharmacy Research | ||
| Article 1, Volume 4, Issue 4, October 2020, Pages 119-138 PDF (1019.12 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2020.27931.1104 | ||
| Authors | ||
| Aisha Y. Hassan* 1; Marwa Sarg2; Ebtehal Husseiny2 | ||
| 1Department of Chemistry, Faculty of Science(Girls), Al-Azhar University, Nasr City, Cairo, Egypt. | ||
| 2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt. | ||
| Abstract | ||
| Objective: This study aimed synthesis of benzothiazole and thiazole derivatives due to the importance of these heterocycles as anticancer. Method: Novel benzothiazole and thiazole derivatives 2-40 were synthesized through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against 60 human cancer cell lines by the National Cancer Institute (NCI). Conclusion: Twelve compounds 4, 6, 10, 12, 13, 16, 18, 20, 21, 25, 28b and 40 wereselected by NCI for evaluation and have anticancer activity. | ||
| Keywords | ||
| Anticancer; Benzothiazole; Thiazole | ||
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