Preventive Role of Soy Protein in Fructose Induced Metabolic Dysfunction in Rats via Inhibition of Nuclear Factor kappa B Pathway | ||
| Journal of Advanced Medical and Pharmaceutical Research | ||
| Article 2, Volume 2, Issue 1, March 2021, Pages 8-15 PDF (631.02 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jampr.2020.47479.1009 | ||
| Authors | ||
| Nahla El-Ashmawy; Eman Khedr; Hoda Elbahrawy; Reham Abdelhamid* | ||
| Biochemistry Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt | ||
| Abstract | ||
| Soy protein is an important component of soybeans that has beneficial role in improving insulin resistance. Nuclear factor kappa B (NF-κB) is a crucial pathway that has been implicated in the development of metabolic syndrome. Our study aimed to examine the protective effect of soy protein isolate - as a natural NF-κB inhibitor - and its possible mechanism of action in amelioration of inflammatory and metabolic disorders induced in male albino rats by high fructose diet (10% w/v) via using synthetic NF-κB inhibitor (IMD-0354). Rats were randomized into normal control group, soy group, NF-κB inhibitor (IMD-0354) group, high fructose group, high fructose with soy group, high fructose with NF-κB inhibitor group, high fructose with soy and NF-κB inhibitor group. Serum glucose, serum insulin, serum free fatty acids, insulin resistance (HOMA-IR), NF-κB, phosphorylated insulin receptor (pISR), carbohydrate-responsive element-binding protein (ChREBP) were determined and histopathological examination of liver tissue was performed. The concurrent administration of IMD-0354 and/or soy protein with high fructose significantly increased pISR and decreased FFAs, NF-κB, glucose, insulin, HOMA-IR, and ChREBP as well as improved the pathological conditions of the livers. The metabolic and inflammatory disorders induced by chronic consumption of fructose could be inhibited by co-administration of soy protein through regulation of NF-κB signalling pathway. | ||
| Keywords | ||
| Fructose; Metabolic Dysfunction; Soy Protein; NF-κB; Insulin Resistance | ||
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