SOLUBLE CD14 AS A BIOMARKER OF SEPSIS AND ITS RELATION TO BLOOD CULTURES IN FEBRILE NEUTROPENIC ACUTE MYELOID LEUKEMIA PATIENTS RECEIVING CHEMOTHERAPY | ||
| ALEXMED ePosters | ||
| Article 29, Volume 2, Issue 2, October 2020, Pages 63-63 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2020.50136.1073 | ||
| Author | ||
| Nahla kamal khalil* | ||
| Departments of internal medicine, Hematology, Faculty of Medicine, University of Alexandria, Egypt | ||
| Abstract | ||
| • The incidence of acute leukemia in Egypt according to the National Population-Based Cancer Registry Program is about 3 cases per 100 000 population. • Acute leukemia is classified according to WHO classification which incorporates clinical, prognostic, morphologic, immunophenotypic, and genetic data. • Manifestations of acute leukemia can result from constitutional symptoms, bone marrow failure , infilteration of other organs and of leukocytosis. • Acute leukemia patients are more prone to infections due to several factors including neutropenia, disruption of mucosal barriers and administration of immune suppressive drugs. • The most popular tool used to predict the risk of complications associated with a febrile neutropenia is the Multinational Association of Supportive Care in Cancer (MASCC) score. • The use of standard culture techniques for the detection and isolation of pathogenic organisms from a sterile body fluid specimen is still considered the “gold standard” for the diagnosis of infection and sepsis. • Bacterial infections are commonly caused by six main etiologies: three Gram-negative (E. coli, Klebsiella sp and Pseudomonas aeruginosa) and three Gram-positive (S. aureus, S. epidermidis and S. Viridans). • Presepsin is a new sepsis marker that show a potential as an early marker of sepsis recognition, for antimicrobial therapy monitoring and as a prognostic marker. • Presepsin (sCD14-ST) is a peptide sized 13 kDa that is generated by proteolytic cleavage of soluble forms of CD14 cluster (sCD14). • The major CRP drawback in sepsis lies in its lack of specificity. | ||
| Keywords | ||
| Febrile Neutropenia; Soluble Cd14; Sepsis | ||
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