El Mohr, M., Faris, M., Bakry, S., Hozyen, H., Elshaer, F. (2020). Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome. test, 12(2), 87-95. doi: 10.21608/eajbsc.2020.125100
Mohamed F. El Mohr; Mohamed Faris; Sayed Bakry; Heba Hozyen; Fathy M. M. Elshaer. "Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome". test, 12, 2, 2020, 87-95. doi: 10.21608/eajbsc.2020.125100
El Mohr, M., Faris, M., Bakry, S., Hozyen, H., Elshaer, F. (2020). 'Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome', test, 12(2), pp. 87-95. doi: 10.21608/eajbsc.2020.125100
El Mohr, M., Faris, M., Bakry, S., Hozyen, H., Elshaer, F. Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome. test, 2020; 12(2): 87-95. doi: 10.21608/eajbsc.2020.125100

Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 7, Volume 12, Issue 2, December 2020, Pages 87-95    PDF (478.63 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2020.125100
Authors
Mohamed F. El Mohr1; Mohamed Faris1; Sayed Bakry2; Heba Hozyen3; Fathy M. M. Elshaer4
1Dr Faris Medical Center for Infertility and Human Reproduction, Heliopolis, Cairo, Egypt
2Laboratory of Molecular Biology and Embryology, Zoology Department, Faculty of Science, Al-Azhar University Nasr City, Cairo, Egypt
3Animal reproduction & Artificial Insemination Department, Veterinary Research Division, National Research Centre, Dokki, Cairo, Egypt
4Department of Biology, College of Science, Jouf University, Sakaka. Saudia Arabia, -Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Abstract
Heavy metals and trace elements adversely affect animal health and the reproductive system and its functions through direct or indirect effects on numerous organs and systems. This study was aimed to evaluate the effect of heavy metals levels in follicular fluid on a patient undergoing Intracytoplasmic Sperm Injection (ICSI) outcomes namely Cadmium (Cd), Lead (Pb), and Arsenic (As). In comparison between the normal concentration level of Cd and the high concentration level of Cd the present study showed a significant difference in embryos quality (P=0.01611), while no statistically significant difference in pregnancy rate was observed. Although Pb showed a significant difference in embryos quality; grade I embryos in normal level concentration than high-level group (P=0.00021), and grade III embryos were significant in a high-level concentration of Pb than low-level group (P=0.0043).  The present study concluded that a high level of heavy metal concentration in the follicular fluid has a harmful effect on the grading of embryos and these lead to a decrease in the chance to select the beast embryos before transferred (Cd and Pb).
Keywords
Cadmium (Cd); Lead (Pb); As (Arsenic); Follicular fluid (FF); Intra Cytoplasmic Sperm Injection (ICSI); heavy metals
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