AMELIORATING EFFECT OF THYMOQUINONE ON THE DELETERIOUS EFFECTS OF MOBILE PHONE RADIATION IN THE RAT BRAIN | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 8, Volume 52, Issue 2 - Serial Number 52, September 2015, Pages 124-139 PDF (608.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2015.12541 | ||
| Author | ||
| El Sayed El Sayed | ||
| Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, Egypt. | ||
| Abstract | ||
| Tremendous concerns have been raised about the possibility that exposure to electromagnetic radiation (EMR) from mobile phones could affect people’s health. Many experimental studies suggest the possible role of reactive oxygen species (ROS) in EMR-induced damage in brain tissues with subsequent neurobehavioral changes. The aim of the present study was to investigate the protective effect of thymoquinone (TQ) on EMR-induced oxidative damage in brain tissue of rats. Results of the current study show that exposure to EMR decreases the time spent in target quadrant of Morris water maze and the percentage time spent in open arms of elevated plus maze, and increases significantly the percentage time spent in closed arms of elevated plus maze, malondialdehyde (MDA), nitric oxide (NO), and norepinephrine (NE) contents in brain tissue. Furthermore, a significant decrease in brain catalase (CAT) activity, reduced glutathione (GSH) contents, serotonin (5-HT) and dopamine (DA) contents were also observed. These alterations were prevented by TQ (5, 10 mg/kg). The observed neuroprotective effects of TQ were attributed to its powerful antioxidant activities. | ||
| Keywords | ||
| Mobile phones radiation; Thymoquinone; Brain monoamines; Oxidative Stress; Morris maze; Elevated plus maze | ||
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