A Simple Synthesis of Some Novel Bi-Thiazoles as Anti-Tumor Agents | ||
| Egyptian Journal of Chemistry | ||
| Article 26, Volume 64, Issue 3, March 2021, Pages 1363-1370 PDF (653.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2020.49043.3002 | ||
| Author | ||
| Sami A. Al-Hussain* | ||
| Department of Chemistry, Faculty of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13318, Saudi Arabia | ||
| Abstract | ||
| Revised Abstract A series of novel bi-thiazoles was synthesized by reaction of 2-(1-(2-(2-(1-(4-fluorophenyl)ethylidene)hydrazinyl)-4-methylthiazol-5-yl)ethylidene) hydrazine-1-carbothioamide 3 with a variety of hydrazonoyl chloride derivatives 4a-d, and 7 a-d affording 6a-d and 9a-d respectively in dioxane in the presence of triethyl amine as a base. Also, hydrazine-1-carbothioamide 3 reacts with substituted phenacyl bromide derivatives 10 a-d yielding 12a-d in appropriate reaction conditions. The mechanisms of the titled reactions were discussed. Structural assignments were based on spectroscopic methods (NMR, FTIR, MS). The new compounds were tested in vitro for their were subjected to in vitro anticancer screening against human hepatocellular carcinoma (HCT-116), (HepG-2) and the results showed that compounds 6a, 6d, 9a, 9c and 12a have promising activities compared with cisplatin reference drug. | ||
| Keywords | ||
| heterocycles; hydrazonoyl halides; cyclization; hydrazones; bi-thiazoles | ||
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