Association of CYP24A1 promoter methylation with hepatocellular carcinoma on top of HCV infection | ||
| Zagazig University Medical Journal | ||
| Article 584, Volume 29, Issue 1.2, January 2023, Pages 220-227 PDF (429.31 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2020.47759.1986 | ||
| Authors | ||
| HUDA SAID* 1; Ebtehag Helmy Hassan2; Nahla Elsayed Elgamal3; maher mohamed borai4 | ||
| 1clinical pathology, fac. medicine, zagazig univeristy. | ||
| 2Clinical pathology Department, Faculty of medicine, Zagazig University, Zagazig, Egypt | ||
| 3Tropical medicine Department, Faculty of medicine, Zagazig University, Zagazig, Egypt | ||
| 4clinical pathology,faculty of medicine,zagazig university,zagazig, egypt | ||
| Abstract | ||
| Background (purpose) Since HCV, infection may lead to hepatocellular carcinoma (HCC) .we investigated if CYP24A1 gene hyper methylation involved in HCC and the relationship between CYP24A1 gene and HCC Methods:-Fifty patients were selected from Tropical Medicine department and outpatient’s clinic of Zagazig University Hospitals. The patients were classified into: 15 patients with chronic HCV patients with cirrhosis, 15 patients with chronic HCV without cirrhosis and 20 patients have HCC on top of HCV .All patients were subjected to proper history taking, full physical examination, laboratory investigations, abdominal U.S and triphasic helical CT as well as real time PCR for detection of hyper methylated CYP24A 1 Results:-The three groups were matched together as regards age and sex. There are a high statistically difference among the three studied groups regarding level of CYP24A1 ,which was higher among HCC group 14.62±7.74 and the lowest level was among HCV group without cirrhosis 5.3±3.46 (P value =0.000) CONCLUSION: CYP24A1 promoter methylation increase in HCC patient on top of HCV infection | ||
| Keywords | ||
| viral hepatitis; hepatocellular carcinoma; CYP24A1; vitamin D; epigenetics | ||
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