AlKhalaf, H., Almezani, A., Almodhaibri, Y., Almusallami, M., Attiah, J., Alsahli, A., Alluqmani, M., Saeedi, F., Alzahrani, A., Al Taha, I., Alsharif, S., ALAjwad, F., Herzallah, N. (2017). Griseofulvin vs. Terbinafine in the Treatment of Tinea Capitis. test, 69(8), 2992-2996. doi: 10.12816/0042845
Humoud Mansour AlKhalaf; Adnan Meteb Mohamed Almezani; Youssef Mohammad Almodhaibri; Mustafa Mohamed Ali Almusallami; Jumanh Khalid Attiah; Abdulaziz Mohammed Alsahli; Maha Fahad Alluqmani; Fatimah Mohammed Saeedi; Ali Hassan Jaber Alzahrani; Ibrahim Abdullah Al Taha; Somaya Khalid Alsharif; Fatema Hassan A. ALAjwad; Nawal Hatem Herzallah. "Griseofulvin vs. Terbinafine in the Treatment of Tinea Capitis". test, 69, 8, 2017, 2992-2996. doi: 10.12816/0042845
AlKhalaf, H., Almezani, A., Almodhaibri, Y., Almusallami, M., Attiah, J., Alsahli, A., Alluqmani, M., Saeedi, F., Alzahrani, A., Al Taha, I., Alsharif, S., ALAjwad, F., Herzallah, N. (2017). 'Griseofulvin vs. Terbinafine in the Treatment of Tinea Capitis', test, 69(8), pp. 2992-2996. doi: 10.12816/0042845
AlKhalaf, H., Almezani, A., Almodhaibri, Y., Almusallami, M., Attiah, J., Alsahli, A., Alluqmani, M., Saeedi, F., Alzahrani, A., Al Taha, I., Alsharif, S., ALAjwad, F., Herzallah, N. Griseofulvin vs. Terbinafine in the Treatment of Tinea Capitis. test, 2017; 69(8): 2992-2996. doi: 10.12816/0042845

Griseofulvin vs. Terbinafine in the Treatment of Tinea Capitis

The Egyptian Journal of Hospital Medicine
Article 8, Volume 69, Issue 8, October 2017, Pages 2992-2996    PDF (226.85 K)
Document Type: Original Article
DOI: 10.12816/0042845
Authors
Humoud Mansour AlKhalaf1; Adnan Meteb Mohamed Almezani2; Youssef Mohammad Almodhaibri3; Mustafa Mohamed Ali Almusallami4; Jumanh Khalid Attiah5; Abdulaziz Mohammed Alsahli6; Maha Fahad Alluqmani5; Fatimah Mohammed Saeedi5; Ali Hassan Jaber Alzahrani7; Ibrahim Abdullah Al Taha8; Somaya Khalid Alsharif9; Fatema Hassan A. ALAjwad10; Nawal Hatem Herzallah1
1Royal college of surgeons in Ireland
2Hail university , College of Medicine
3Qassim University
4Hera General Hospital
5ibn sina national college
6King Abdulaziz university
7ing Abdulaziz university-Rabigh branch
8Oyun City Hospital
9Umm Al-Qura University
10Imam abdulrahman bin faisal university
Abstract
Background: Two oral antifungal agents, griseofulvin and terbinafine, have regulatory approval but it is unknown whether one has superior overall efficacy. Genus-specific differences in efficacy are believed to exist for the two agents. It is not clear at what doses and durations of treatment these differences apply.
Purpose: The purposes of this meta-analysis were to determine whether a statistically significant difference in efficacy exists between these agents at a given dose and duration of each in tinea capitis infections overall and to determine whether a genus-specific difference in efficacy exists for these two treatments at a given dose and duration of each. We performed a literature search for clinically and methodologically similar randomized controlled trials comparing 8 weeks of griseofulvin (6.25–12.5 mg⁄kg⁄day) to 4 weeks of terbinafine (3.125–6.25 mg⁄kg⁄day) in the treatment of tinea capitis. A meta-analysis was performed using the Mantel–Haenszel method and random effects model; results were expressed as odds ratios with 95%.  
Results: Meta-analysis of randomized controlled trials did not show a significant difference in the overall efficacy of the two drugs at the doses specified, but specific efficacy differences were observed based on the infectious species. For tinea capitis caused by Microsporumspp., griseofulvin is superior (p = 0.04), whereas terbinafine is superior for Trichophyton spp. infection (p = 0.04).
Conclusion:Our results support species-specific differences in treatment efficacy between griseofulvin and terbinafine and provide a clinical context in which this knowledge may be applied.
 
Keywords
Griseofulvin; Terbinafine; Tinea Capitis
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